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Haemodynamic aspects of clinical cerebral angiography concurrent two vessel monitoring using transcranial Doppler ultrasound

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Summary

To overcome the technical limitations which have precluded noninvasive Doppler ultrasound in investigation of rapid cerebral haemodynamic responses in two cerebrovascular beds at the same time, we have modified a commercial 2 MHz pulsed Doppler instrument with online spectrum analysis. Two probes are activated intermittently, recording eight averaged Doppler-shifted spectra from each probe sequentially.

Concurrent recordings of blood velocity in both middle cerebral arteries were performed during 25 selective iohexol carotid angiography runs in 13 patients with near normal cerebral vasculature. The technique permitted the differentiation between the specific responses confined to the recipient vascular bed, and the general responses occurring in remote brain areas as well. The specific response to iohexol was biphasic; a significant decrease in blood velocity occurred <4 s after the bolus entry, probably due to the high viscocity of iohexol. Between 4 and 12s, blood velocity was significantly increased, reflecting the cerebrovascular response to hypertonic solutions. The blood velocity on the opposite side increased from <4 s through 45 s after iohexol. This concurs with studies using electromagnetic flowmetry, and suggests that these general responses are elicited by anxiety, discomfort and pain. Thus, no general responses were seen during angiography under general anaesthesia.

Eight patients investigated during catheter flushing with normal saline showed a biphasic specific response reciprocal to that due to iohexol. A significant blood velocity peak occurred < 4 s after the bolus entry, followed by a decrease between 4 and 60 s. The saline injections produced no pain and evoked no significant general response.

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Authors and Affiliations

  1. Departments of Neurosurgery and Radiology (Neuroradiology Section), Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway

    H. Nornes, W. Sorteberg, P. Nakstad, S. J. Bakke, R. Aaslid & K. -F. Lindegaard

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  1. H. Nornes
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  2. W. Sorteberg
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  3. P. Nakstad
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  4. S. J. Bakke
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  5. R. Aaslid
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  6. K. -F. Lindegaard
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Acknowledgement: Supported by The Norwegian Council on Cardiovascular Diseases.

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Nornes, H., Sorteberg, W., Nakstad, P. et al. Haemodynamic aspects of clinical cerebral angiography concurrent two vessel monitoring using transcranial Doppler ultrasound. Acta neurochir 105, 89–97 (1990). https://doi.org/10.1007/BF01669989

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  • DOI: https://doi.org/10.1007/BF01669989

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