Summary
The case of a 39-year-old patient with ectopic Cushing's syndrome due to a metastatic carcinoid tumor is presented. Palliative therapy consisting of 800 mg ketokonazole and 0.3 mg SMS 201-995/die resulted in clinical remission and correction of hypokaelmia and hypercortisoluria. Combined therapy was clearly superior to monotherapy with ketokonazole or SMS 201-995, respectively. Side effects were not observed, the tumor masses remained unchanged throughout the observation period of now 19 months.
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Abbreviations
- ACTH:
-
adrenocorticotropic hormone
- o′p′DDD:
-
1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)-ethane
- 5-HIAA:
-
5-hydroxyindolaceticacid
- VIP:
-
vasoactive intestinal pepide
- CRH:
-
corticotropin releasing hormone
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Kornely, E., Schlaghecke, R. & Horster, F.A. Palliative therapy of an ectopic cushing's syndrome due to a metastatic carcinoid tumor. Klin Wochenschr 69, 173–176 (1991). https://doi.org/10.1007/BF01665863
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DOI: https://doi.org/10.1007/BF01665863