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Non-cytotoxic asialo-GM1-positive cells exert antimetastatic activity

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Summary

Metastasis can be inhibited by asialo-GM1-positive spleen cells, and in this paper we show that there are two such spleen cell populations. One population is adherent and non-cytotoxic to YAC cells, whereas the other population is non-adherent and cytotoxic to YAC cells. Both cell populations exert an antimetastatic activity in cyclophosphamide-treated mice that are inoculated with LL2 Lewis lung carcinoma cells. We conclude that the antimetastatic activity is not only exerted by cytotoxic asialo-GM1-positive cells (apparently natural killer cells), but also by adherent, non-cytotoxic asialo-GM1+, Thy1.2−, IgG− cells. This means that the latter exert their antimetastatic activity by a non-cytotoxic mechanism.

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Authors and Affiliations

  1. Institute of Immunology and Experimental Therapy, Czerska 12, 53-114, Wroclaw, Poland

    Leon Strzadala, Ianusz Rak, Ewa Ziolo, Maria Paprocka & Czeslaw Radzikowski

  2. Pathologisch Instituut, Pasteurstraat 2, 3511 HX, Utrecht, The Netherlands

    Leon Strzadala & Willem Den Otter

Authors
  1. Leon Strzadala
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  2. Ianusz Rak
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  3. Ewa Ziolo
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  4. Maria Paprocka
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  5. Czeslaw Radzikowski
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  6. Willem Den Otter
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Strzadala, L., Rak, I., Ziolo, E. et al. Non-cytotoxic asialo-GM1-positive cells exert antimetastatic activity. Cancer Immunol Immunother 30, 51–56 (1989). https://doi.org/10.1007/BF01665030

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  • DOI: https://doi.org/10.1007/BF01665030

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