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A double-blind comparison of the clinical tolerance of bacampicillin and pivampicillin

A preliminary report

Doppelblind-Vergleich der klinischen Verträglichkeit von Bacampicillin und Pivampicillin

Vorläufiger Bericht

  • Clinical Evaluation
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Summary

In this double-blind study, the clinical tolerance of high doses of bacampicillin hydrochloride (800 mg t. i. d.) and of pivampicillin base (700 mg t. i. d.) administered for ten days were compared in out-patients with acute urinary tract infections. The clinical response was comparable with that previously reported for those antibiotics. Upper gastrointestinal side-effects were more common after treatment with pivampicillin and were reported in 9/38 patients compared to 3/34 patients treated with bacampicillin. The duration of the symptoms of the side-effects was also more prolonged after pivampicillin than after bacampicillin.

Zusammenfassung

In dieser Doppelblindstudie wurde die klinische Verträglichkeit hoher Dosen von Bacampicillin-Hydrochlorid (800 mg dreimal/die) und von Pivampicillin-Base (700 mg, dreimal/die) verglichen, die zehn Tage lang an ambulante Patienten mit akuten Harnwegsinfekten verabreicht wurden. Der klinische Therapieerfolg war vergleichbar mit früheren Berichten über diese Antibiotika. Beschwerden von seiten des oberen Gastro-Intestinal-Traktes waren nach Behandlung mit Pivampicillin häufiger, sie traten bei 9/38 Patienten unter Pivampicillin und bei 3/34 Patienten unter Bacampicillin auf. Die Dauer der Symptome der Nebenwirkungen war bei Pivampicillin außerdem länger als bei Bacampicillin.

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Literature

  1. Swahn, Å. Gastrointestinal absorption and metabolism of two35S-labelled ampicillin esters. Europ. J. Clin. Pharmacol. 9 (1976) 299–306

    Google Scholar 

  2. Brumfitt, W., Franklin, I., Hayck, L., Pursell, R. Treatment of urinary tract infection with pivampicillin. Scand. J. Infect. Dis. 5 (1973) 59–65.

    Google Scholar 

  3. Hallander, H., Flodström, A., Sjövall, J. Pharmacological and clinical study of bacampicillin in acute peritonsillitis — a comparison with ampicillin. Antimicrob. Ag. Chemother. 11 (1977) 185–190.

    Google Scholar 

  4. Olsson, O., Henning, C. Clinical study on bacampicillin in otitis media acuta and sinusitis acuta. Proceedings of the 9th International Congress of Chemotherapy, London 1975, Chemotherapy vol. 5. Plenum Press, New York 1976, p. 145.

    Google Scholar 

  5. Raunio, V., Jokinen, K., Karjalainen, S. Clinical, bacteriological and pharmacological study of bacampicillin in chronic maxillary sinusitis — a comparison with ampicillin. Proceedings of the 9th International Congress of Chemotherapy, London 1975, Chemotherapy vol. 5. Plenum Press, New York 1976, p. 151.

    Google Scholar 

  6. Berg, K. J., Widerøe, T. E. Pivampicillin chloride in the treatment of urinary tract infection in a medical department. Chemotherapy 18 (1973) 130–136.

    Google Scholar 

  7. Danø, P., From Hansen, P. Antibiotic treatment with pivampicillin chloride in respiratory and urinary tract infections. Chemotherapy 18 (1973) 63–71.

    Google Scholar 

  8. Maesen, F., Buytendijk, H. J., Beeuwkes, H. Clinical experience with pivampicillin in chronic bronchitis. Scand. J. Resp. Dis. 55 (1974) 245–255.

    Google Scholar 

  9. Hey, H., Medalen, T. J., Mølstad, O. M., Stokholm, K. A clinical evaluation of the tolerance to pivampicillin tablets. Infection 5 (1977) 22–25.

    Google Scholar 

  10. Nilsson, L.-B. Klinisk värdering av pivampicillin (Pondocillin®) tabletter. Opusc. Med. 42 (1976) 119–120.

    Google Scholar 

  11. Davies, B. I., Maesen, F., Brombacher P. J., Sjövall, J. Twice daily dosage of bacampicillin in chronic bronchitis — a double-blind study. Scand. J. Resp. Dis. 59 (1978) 283.

    Google Scholar 

  12. Magni, L., Sjöberg, B., Sjövall, J., Wessman, J. Clinical pharmacological studies with bacampicillin: In:Williams, J. O., Geddes, A. M. (eds): Chemotherapy vol. 5, Penicillins and Cephalosporins. Plenum Press, New York 1976, p. 109.

    Google Scholar 

  13. Kaipainen, W. J., Timonen, T., Raunio, V. Clinical study of bacampicillin in urinary tract infections — a comparison with ampicillin: In:Williams, J. O., Geddes, A. M. (eds.): Chemotherapy vol. 5, Penicillins and Cephalosporins. Plenum Press, New York 1976, p. 131.

    Google Scholar 

  14. Tuomaala, R. Bacampicillin and ampicillin in general practice: double-blind comparison in urinary tract infections: In:Siegenthaler, E., Lüthy, R. (eds.): Current Chemotherapy I, Proceedings of the 10th International Congress of Chemotherapy, Zürich 1977. Publ. by: Am. Soc. Microbiol., Washington DC, 1978, p. 207.

    Google Scholar 

  15. Ekström, B., Forsgren, U., Magni, L., Sjöberg, B., Sjövall, J., Tolf, R. Bacampicillin, a well-absorbed pro-drug of ampicillin — a report on properties and clinical experiences. J. Drug Res. 2 (1977) 39.

    Google Scholar 

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Authors and Affiliations

  1. Vårdcentralen, 56100, Huskvarna, Sweden

    Å. Koldestam &  S. Olsson

  2. Medical Department, Astra Läkemedel AB, 15185, Södertälje, Sweden

    L. Berglund

Authors
  1. Å. Koldestam
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  2. S. Olsson
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  3. L. Berglund
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Koldestam, Å., Olsson, S. & Berglund, L. A double-blind comparison of the clinical tolerance of bacampicillin and pivampicillin. Infection 7 (Suppl 5), S495–S498 (1979). https://doi.org/10.1007/BF01659782

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  • DOI: https://doi.org/10.1007/BF01659782

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