Abstract
From 1959 to 1987, a total of 1,182 histologically proven breast cancer patients were followed. Of these, 48 (4.06%) with bilateral breast carcinoma were reviewed. Eight patients (0.68%) had simultaneous breast carcinomas and the remaining 40 (3.38%) had nonsimultaneous breast carcinomas. The period between the development of the first and second primary carcinoma ranged from 17 to 200 months (mean, 86 months). The second primary carcinoma was found symetrically located with the first primary carcinoma in only 34.5% of the cases. No significant differences were observed between the bilateral carcinoma patients and the unilateral carcinoma patients with respect to pregnancy, delivery, family history, and the size and localization of the carcinomas. Axillary metastasis was seen in a higher percentage of the second primary carcinomas (48% versus 37.5%). It was observed that the shorter the time interval between the presentation of the carcinomas, the shorter the survival.
Résumé
Nous avons suivi de 1959 à 1987 1,182 patientes ayant un cancer du sein histologiquement prouvé. Nous en avons revu 48 (4.06%) ayant un cancer du sein bilatéral. Huit patientes (0.68%) avaient un cancer du sein bilatéral simultané et les 40 autres (3.38%) un cancer du sein bilatéral dont le deuxième était découvert entre 17 à 200 mois (moyenne, 86 mois) après le premier. Le second cancer primitif était symétrique au premier cancer primitif dans 34.5% des cas seulement. Nous n'avons pas observé de différence significative entre les patientes ayant un cancer bilatéral et celles qui avaient un cancer unilatéral en ce qui concerne grossesse, accouchement, antécédent familiaux, et taille et localisation des cancers. Nous avons observé un pourcentage plus fort de métastases axillaires des deuxièmes cancers primitifs (48% pour 37.5%). Nous avons constaté que plus était court l'intervalle entre l'apparition des cancers plus était courte la survie.
Resumen
Entre los años 1959 y 1987, un total de 1,182 pacientes con cancer mamario comprobado histológicamente fueron seguidas. De éstas, 48 (4.06%) presentaron carcinoma mamario bilateral y son el objeto de esta revisión; 8 (0.68%) lo presentaron simultáneamente y las otras 40 (3.38%) no simultáneamente. El período entre el desarrollo del primero y el segundo carcinoma primario varió entre 17 y 200 meses (promedio, 86 meses). El segundo carcinoma primario fue hallado simétricamente ubicado en relación al primero en sólo 34.5% de los casos. No se encontraron diferencias significativas entre las pacientes con carcinoma bilateral y los que presentaron carcinoma unilateral con relación a embarazos, partos historia familiar o tamaño y ubicación de los carcinomas. Se registraron metástasis axilares en un mayor porcentaje en los segundos carcinomas primarios (48% versus 37.5%). Se observó que entre más corto el intervalo entre la presentación de uno y otro carcinoma, más corta la supervivencia.
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Gülay, H., Hamaloglu, E., Bulut, O. et al. Bilateral breast carcinoma: 28 years' experience. World J. Surg. 14, 529–533 (1990). https://doi.org/10.1007/BF01658684
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DOI: https://doi.org/10.1007/BF01658684