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Bilateral Breast Cancer: Clinical Profile and Management

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Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

There is paucity of literature regarding the demography, histopathology, management, and outcomes of bilateral breast cancer (BBC). We present our experience of treating 127 BBC with multimodality management. An audit of prospectively maintained computerized breast cancer database of the department of surgical oncology at a tertiary care center was performed. Demography, clinical profile, molecular sub-types, treatment patterns, and outcomes were analyzed. A total 127 patients presented with BBC between 1992 and 2019. Ninety-four had metachronous (MBBC) and 33 had synchronous breast cancer (SBBC). Most contralateral breast cancer (CBC) patients had early-stage breast cancer in comparison to the index side cancer (37% vs 32%). Ninety-four patients underwent bilateral mastectomy and only 18 patients underwent bilateral breast conservation. Seventy-one patients undergoing BCS and surgery for LABC were given postoperative radiotherapy. All patients received adjuvant chemo- and/or hormonal therapy both for index and CBC based on the stage and hormone receptor status. Thirty-three percent of patients had either locoregional or distant relapse. The 5-year overall survival (OS) and 5-year disease-free survival (DFS) of the entire cohort were 86.6% and 68.4% respectively. There was no difference in the OS and DFS between SBBC and MBBC. The incidence of BBC is expected to increase with effective diagnostic and therapeutic interventions and improving survival. Patients require individualized treatment planning in a multidisciplinary treatment setting.

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Data Availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Author information

Authors and Affiliations

  1. Department of Surgical Oncology, BRA-IRCH, AIIMS, New Delhi, India

    Ashutosh Mishra, Ajit Singh Oberoi, Suryanarayana Deo & Jyoti Sharma

  2. Department of Medical Oncology, BRA-IRCH, AIIMS, New Delhi, India

    Ajay Gogia

  3. Department of Radiation Oncology, BRA-IRCH, AIIMS, New Delhi, India

    D. N. Sharma

  4. Department of Pathology, AIIMS, New Delhi, India

    Sandeep Mathur

  5. Department of Radiology, AIIMS, New Delhi, India

    Ekta Dhamija

Authors
  1. Ashutosh Mishra
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  2. Ajit Singh Oberoi
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  3. Suryanarayana Deo
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  4. Jyoti Sharma
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  6. D. N. Sharma
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Contributions

Guarantor of integrity of the entire study: Ashutosh Mishra, SVS Deo.

Study concepts and design: All authors.

Literature research: Ashutosh Mishra, Ajit Singh Oberoi, SVS Deo.

Clinical studies: All authors.

Experimental studies/data analysis: Ashutosh Mishra, Ajit Singh Oberoi, SVS Deo.

Statistical analysis: Ajit Singh Oberoi, SVS Deo.

Manuscript preparation: Ashutosh Mishra, Ajit Singh Oberoi, SVS Deo.

Manuscript editing: All authors.

All authors commented and contributed in revising the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Suryanarayana Deo.

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Ethical Approval

For this type of study, ethical approval is not required since it was a retrospective analysis of a database.

Informed Consent

Informed consent was not required for this study since it was a retrospective analysis of a database.

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The authors declare no competing interests.

Research Involving Human Participants and/or Animals

This article does not contain any studies with animals performed by any of the authors.

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Mishra, A., Oberoi, A.S., Deo, S. et al. Bilateral Breast Cancer: Clinical Profile and Management. Indian J Surg Oncol 14, 651–658 (2023). https://doi.org/10.1007/s13193-023-01731-x

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  • DOI: https://doi.org/10.1007/s13193-023-01731-x

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