Abstract
Familial occurrence of differentiated, nonmedullary thyroid carcinoma in 23 patients from 11 families is reported. Five patients were male and 18 were female. The familial relationship of patients was “parent and child” in 12 cases from 6 families, and “siblings” in 11 cases from 5 families. Carcinoma of other organs was noted in other members in 8 families. Histological examination revealed 18 papillary, 2 follicular, and 2 anaplastic carcinomas (the 2 anaplastic carcinomas were considered to be transformed from preexisting differentiated carcinoma). In 1 case, the histological type was unknown. The average diameter of the primary lesion was 29.9 mm. Cervical lymph node metastasis was found in 77.8% and local recurrence in 28.6% of the patients. Solid and invasive growth was dominant. On HLA typing, phenotypes of B7 and DR1 were significantly redominant in familial patients compared with nonfamilial patients and normal Japanese. Moreover, the haplotype of B7-Cw7-DR1 was observed in 5 of 13 patients tested.
It is suggested from these observations that some types of differentiated, nonmedullary thyroid carcinoma may show familial occurrence and that they may have common factors with regard to the genetic and immunologic basis of the disease.
Résumé
On a étudié les caratéristiques du cancer de la thyroïde, dans sa variété différenciée non médullaire, survenu chez 23 patients provenant de 11 familles. Cinq patients étaient des hommes, 18 des femmes. La relation familiale était parent/enfant dans 12 cas provenant de 6 familles, et frère/soeur dans 11 cas provenant de 5 familles. Des membres de 8 autres familles présentaient un cancer d'un autre organe. Il y avait 18 cancers papillaires, 2 cancers folliculaires, et 2 cancers anaplasiques (on a considéré que les 2 cancers anaplasiques étaient des transformations à partir de cancers différenciés préexistants). Dans un cas, le type histologique était inconnu. Le diamètre moyen de la lésion primitive était de 29.9 mm. On a retrouvé des métastases ganglionnaires cervicales chez 77.8% des patients et une récidive locale chez 28.6%. Les tumeurs étaient principalement solides et invasives. Par rapport aux cancéreux non familiaux et à la population japonaise normale, il y avait plus de phénotypes B7 et DR1 au système HLA. L'haplotype B7-CW7-DR1 était observé chez 5 des 13 patients testés.
On suggère que certains types de cancer différenciés, non médullaires, ayant des facteurs communs génétiques et immunologiques, peuvent survenir dans une même famille.
Resumen
Se informa la ocurrencia familiar de carcinoma bien diferenciado, no medular, de tiroides en 23 pacientes provenientes de 11 familias, 5 hombres y 18 mujeres. La relación familiar fue “padre e hijo” en 12 casos de 6 familias, y “hermanos” en 11 casos de 5 familias. Se observé la presencia de carcinoma de otros órganos en otros miembros de 8 familias. El examen histopatológico reveló 18 carcinomas papilares, 2 foliculares, y 2 anaplásicos (los 2 fueron considerados como transformación de carcinomas diferenciados preexistentes). En un caso no fue conocido el tipo histológico. El diámetro promedio de la lesión primaria fue 29.9 mm. Se hallaron metástasis en ganglios cervicales en 77.8% de los pacientes y recurrencia local en 28.6%. El crecimiento sólido e invasivo apareció como característica dominante. En la tipificación HLA aparecieron como significativamente predominantes los fenotipos de B7 y DR1 en pacientes familiares en comparación con pacientes no familiares y japoneses normales. Por otra parte, el halotipo de B7-CW7-DR1 fue observado en 5 de 13 pacientes investigados.
Como resultado de estas observationes se sugiere que algunos tipos de carcinomas diferenciados, no medulares, pueden demostrar ocurrencia familiar y que pueden poseer factores comunes relacionados con las bases genéticas e inmunológicas de la enfermedad.
Similar content being viewed by others
References
Camiel, M.R., Mulé, J.E., Alexander, L.L., Benninghoff, D.L.: Association of thyroid carcinoma with Gardner's syndrome in siblings. N. Engl. J. Med.278:1056, 1968
Smith, W.G.: Familial multiple polyposis: Research tool for investigating the etiology of carcinoma of the colon? Dis. Colon Rectum11:17, 1968
Elman, D.S.: Familial association of nerve deafness with nodular goiter and thyroid carcinoma. N. Engl. J. Med.259:219, 1958
Robinson, D.W., Orr, T.G.: Carcinoma of the thyroid and other diseases of the thyroid in identical twins. Arch. Surg.70:923, 1965
Lacour, J., Vignalou, J., Perez, R., Gérard-Marchant, R.: Epithelioma papillaire du corps thyroïde. A propos de deux cas familiaux. Nouv. Presse Méd.2:2249, 1973
Němec, J., Soumar, J., Zamrazil, V., Pohunková, D., Motlik, K., Miřejovský, P.: Familial occurrence of differentiated (non-medullary) thyroid cancer. Oncology32:151, 1975
Fisher, C., Edmonds, C.J.: Papillary carcinoma of the thyroid in two brothers after chest fluoroscopy in childhood. Br. Med. J.281:1600, 1980
Lote, K., Andersen, K., Nordal, E., Brennhovd, I.O.: Familial occurrence of papillary thyroid carcinoma. Cancer46:1291, 1980
Phade, V.R., Lawrence, W.R., Max, M.H.: Familial papillary carcinoma of the thyroid. Arch. Surg.116:836, 1981
Borup Christensen, S., Ljungberg, O.: Familial occurrence of papillary thyroid carcinoma. Br. J. Surg.70:508, 1983
Flannigan, G.M., Clifford, R.P., Winslet, M., Lawrence, D.A.S., Fiddian, R.V.: Simultaneous presentation of papillary carcinoma of thyroid in a father and son. Br. J. Surg.70:181, 1983
Suzuki, S., Watanabe, I.: Familial occurrence of papillary thyroid carcinoma. Jpn. J. Cancer Clin.31:414, 1985 (in Japanese with English abstract)
Terasaki, P.I.: Histocompatibility Testing 1980, UCLA Tissue Typing Laboratory, Los Angeles, 1980
Smith, W.G., Kern, B.B.: The nature of the mutation in familial multiple polyposis: Papillary carcinoma of the thyroid, brain tumors, and familial multiple polyposis. Dis. Colon Rectum16:264, 1973
Lynch, H.T., Lynch, P.M., Albano, W.A., Edney, J., Organ, C.H., Lynch, J.F.: Hereditary cancer: Ascertainment and management. Cancer29:216, 1979
DeGroot, L., Paloyan, E.: Thyroid carcinoma and radiation. A Chicago endemic. J.A.M.A.255:487, 1973
Lynch, H.T., Thomas, R.J., Terasaki, P.I., Ting, A., Guirgis, H.A., Kaplan, A.R., Magee, H., Lynch, J., Kraft, C., Chaperon, E.: HL-A in cancer family “N.” Cancer36:1315, 1975
Panza, N., Del Vecchio, L., Maio, M., De Felice, M., Lombardi, G., Minozzi, M., Zappacosta, S.: Strong association between an HLA-DR antigen and thyroid carcinoma. Tissue Antigens20:155, 1982
Sridama, V., Hara, Y., Fauchet, R., DeGroot, L.J.: Association of differentiated thyroid carcinoma with HLA-DR7. Cancer56:1086, 1985
Dralle, H., Robin-Winn, M., Reilmann, L., Laue, A., Török, M.: HLA und Schilddrüsencarcinom. Klin. Wochenschr.64:522, 1986
Juhasz, F., Balázs, G., Stenszky, V., Kozma, L., Farid, N.R.: The relation of susceptibility to and biologic behavior of thyroid epithelial cell cancer to HLA-DR1. Cancer58:52, 1986
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ozaki, O., Ito, K., Kobayashi, K. et al. Familial occurrence of differentiated, nonmedullary thyroid carcinoma. World J. Surg. 12, 565–571 (1988). https://doi.org/10.1007/BF01655453
Issue Date:
DOI: https://doi.org/10.1007/BF01655453