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Haemostasis during treatment with ciprofloxacin

Blutgerinnung unter Ciprofloxacin-Therapie

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Summary

The effects of ciprofloxacin, a new quinolone derivative with high activity on gram-negative aerobic bacteria and gram-positive cocci, on haemostasis were investigated in 11 healthy volunteers. No influence on platelet function was detectable. In some cases a slight reduction in antithrombin III activity was observed at the end of the therapy. No other changes were evident in the plasma coagulation parameters.

Zusammenfassung

Bei 11 gesunden Probanden wurde die Wirkung von Ciprofloxacin, einem neuen Derivat aus der Reihe der Chinolone mit hoher Aktivität gegenüber gramnegativen, aeroben Bakterien und grampositiven Kokken, auf die Hämostase untersucht. Eine Beeinflussung der Thrombozytenfunktion war nicht nachweisbar. In der plastischen Gerinnung fand sich bei einigen Probanden ein leichter Abfall des Antithrombin III am Therapieende, ansonsten kam es zu keinen signifikanten Änderungen der Parameter.

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Authors and Affiliations

  1. Center of Internal Medicine, J. W. Goethe University, D-6000, Frankfurt am Main

    M. Ziemen &  K. Breddin

  2. Division of Angiology and Infections Laboratory, J. W. Goethe University, D-6000, Frankfurt am Main

    P. M. Shah

Authors
  1. M. Ziemen
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  2. K. Breddin
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  3. P. M. Shah
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Ziemen, M., Breddin, K. & Shah, P.M. Haemostasis during treatment with ciprofloxacin. Infection 16 (Suppl 1), S65–S68 (1988). https://doi.org/10.1007/BF01650512

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