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Gram-Negative Infections

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Infection Management in Hematology

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

Abstract

During the last 50 years, two major shifts could be noticed in the epidemiology of bacteria causative for infections and particularly bloodstream infections in febrile neutropenic cancer patients. Until the mid-1980s, gram-negative bacteria, particularly Escherichia coli and Pseudomonas aeruginosa, were the main infectious agents in these patients. Then, presumably due to the increased use of high-intensity chemotherapeutic regimens leading to a higher incidence of severe mucositis, the frequent use of fluoroquinolone (FQ) prophylaxis and indwelling long-term vascular catheters, gram positives, particularly coagulase-negative staphylococci and viridans streptococci, became the dominant infecting agents.

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Authors and Affiliations

  1. Infectious Diseases Clinic, Policlinico San Martino Hospital – IRCCS, Genoa, Italy

    Matteo Bassetti

  2. Department of Health Sciences, University of Genoa, Genoa, Italy

    Matteo Bassetti

  3. Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, Verona, Italy

    Elda Righi

  4. Department of Infectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey

    Murat Akova

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  1. Matteo Bassetti
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  2. Elda Righi
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  3. Murat Akova
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  1. Department I for Internal Medicine, CECAD Translational Research Institute, University Hospital of Cologne, Cologne, Germany

    Oliver A. Cornely

  2. Department of Internal Medicine, Medical University of Graz, Graz, Steiermark, Austria

    Martin Hoenigl

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Bassetti, M., Righi, E., Akova, M. (2021). Gram-Negative Infections. In: Cornely, O.A., Hoenigl, M. (eds) Infection Management in Hematology. Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-030-57317-1_12

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