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Thrombozytenfunktion und Thrombozyten-assoziierte Immunglobuline bei Patienten mit systemischem Lupus erythematodes und chronischer Polyarthritis

Impaired in vitro platelet functions in patients with systemic lupus erythematosus and rheumatoid arthritis

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Summary

The investigation of in vitro platelet functions from patients with SLE and rheumatoid arthritis (RA) revealed a distinctly reduced aggregation mass after both collagen und ADP induction. The platelet serotonin contents were significantly decreased in both groups. An “aspirin-like” platelet defect could be excluded by finding a normal malonyldialdehyde release of patients' platelets upon thrombin stimulation. Significantly increased platelet associated IgG was also detected, whereas platelet associated IgM remained within normal limits. These results are interpreted as indicating an ongoing platelet release reaction induced by IgG platelet antibodies, which induce the observed impairment of platelet functions and may also lead to the release of proinflammatory platelet mediators.

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Abbreviations

ACD:

ACD-Lösung nach USP-Formel A (Dextrose 2,45 ng; Natriumcitrat 2,2 g; Zitronensäure 0,8 g; Aqua bidest ad 100,0)

ADP:

Adenosindiphosphat

ATP:

Adenosintriphosphat

Β-TG:

Β-Thromboglobulin

cP:

chronische Polyarthritis (rheumatoid arthritis)

ELISA:

enzyme-linked immunosorbent assay

MDA:

Malonyldialdehyd

PRP:

platelet rich plasma (thrombozytenreiches Plasma)

PPP:

platelet poor plasma (thrombozytenarmes Plasma)

SLE:

systemischer Lupus erythematodes

TAIgA:

Thrombozyten-assoziiertes IgA

TAIgE:

Thrombozyten-assoziiertes IgE

TAIgG:

Thrombozyten-assoziiertes IgG

TAIgM:

Thrombozyten-assoziiertes IgM

Thr:

Thrombozyten

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Authors and Affiliations

  1. Zentrum für Innere Medizin und Dermatologie, Deutschland

    A. Horn, H. J. Avenarius & H. Deicher

  2. Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover, Deutschland

    A. Horn & H. Deicher

  3. Abteilung Hämatologie und Onkologie, Medizinische Hochschule Hannover, Deutschland

    H. J. Avenarius

Authors
  1. A. Horn
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  2. H. J. Avenarius
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  3. H. Deicher
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Mit Unterstützung der Deutschen Forschungsgemeinschaft, SFB 54-G3

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Horn, A., Avenarius, H.J. & Deicher, H. Thrombozytenfunktion und Thrombozyten-assoziierte Immunglobuline bei Patienten mit systemischem Lupus erythematodes und chronischer Polyarthritis. Klin Wochenschr 68, 460–465 (1990). https://doi.org/10.1007/BF01648899

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  • DOI: https://doi.org/10.1007/BF01648899

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