Summary
The incorporation of the stable isotope15N in plasma proteins and blood cells after oral application of 3 g15NH4Cl (95 At%15N) per 70 kg body weight was followed up in 11 patients with ischemic heart disease or peripheral arteriosclerosis and in 7 healthy control subjects. Preliminary results indicate that the turnover of plasma protein, especially fibrin, is elevated in patients with arteriosclerosis. Investigations of platelets intimate a decreased turnover of platelet protein in patients with arteriosclerosis as compared to control subjects. Possible reasons for these alterations are discussed.
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Barleben, H., Wagenknecht, C., Jung, K. et al. 15N-Tracertechnische Untersuchungen zum Eiweißstoffwechsel bei Arteriosklerosepatienten. Klin Wochenschr 68, 518–522 (1990). https://doi.org/10.1007/BF01648246
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DOI: https://doi.org/10.1007/BF01648246