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AIDS: No association with the genetic systems GC (D-binding protein), ORM (orosomucoid = alpha-1-acid glycoprotein), and A2HS (alpha-2-HS-glycoprotein)

AIDS: Kein Zusammenhang mit den genetischen Systemen GC (Vitamin-D-bindendes Protein), ORM (Orosomukoid = Alpha-1-saures Glykoprotein) und A2HS (Alpha-2-HS-Glykoprotein)

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Summary

In a sample of 97 HIV-1 seropositive persons which comprised 34 patients with AIDS, 30 patients with persistent generalized lymphadenopathy or with AIDS related complex and 33 persons who were without symptoms and called “healthy”, three genetic marker systems were examined: 1) GC, the group-specific component of serum which is identical with the vitamin D binding protein (DBP) of serum, 2) ORM, the acute phase protein orosomucoid = alpha-1-acid glycoprotein of serum, and 3) A2HS, the alpha-2-AS glycoprotein of serum. The distribution of the genotypes and of the alleles in the sample of AIDS patients and of HIV-1/positive persons was not different from the distribution in control groups. An association between susceptibility and/or resistance for AIDS and these genetic marker systems was not observed.

Zusammenfassung

Eine Stichprobe von 97 HIV-1 seropositiven Personen wurde untersucht, darunter befanden sich 34 Patienten mit AIDS, 30 Patienten mit persistierender generalisierter Lymphadenopathie sowie 33 Personen ohne jegliche Symptome, die als “gesund” bezeichnet wurden. In dieser Stichprobe wurden drei genetische Systeme von Plasmaproteinen untersucht: 1. GC, die gruppenspezifische Komponente des Serums, die mit dem Vitamin-D-bindenden Protein (DBP) identisch ist, 2. Orosomukoid, das akute-Phase Protein Orosomukoid, welches auch als Alpha-1-saures Glykoprotein bezeichnet wird und 3. A2HS, das anti-akute-Phase Protein Alpha-2-HS-Glykoprotein. Die Verteilung der Genotypen und der Allele in diesen drei Systemen entsprach bei Patienten mit AIDS und bei HIV-1 seropositiven Personen der Verteilung bei Kontrollgruppen. Ein Zusammenhang zwischen Anfälligkeit für, bzw. Resistenz gegen AIDS und diesen drei genetischen Systemen besteht nicht.

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Literature

  1. Eales, L. J., Nye, K. E., Parkin, J. M., Weber, J. N., Forster, S. M., Harris, J. R. W., Pinching, A.J. Association of different allelic forms of group specific component with susceptibility to and clinical manifestation of human immunodeficiency virus infection. Lancet I (1987) 999–1002.

    Google Scholar 

  2. Constans, J., Viau, M. Group specific component: evidence for two subtypes of the Gc1 gene. Science 198 (1977) 1070–1071.

    Google Scholar 

  3. Cleve, H. The variants of the group-specific component. A review of their distribution in human populations. Israel J. Med. Sciences 9 (1973) 1133–1145.

    Google Scholar 

  4. Kitchin, F. D., Bearn, A. G., Alpers, M., Gajdusek, D. C. Distribution of the inherited serum group-specific protein (Gc) pheno-types in New Guineans. An association of Kuru and the GC Ab phenotype. Am. J. Hum. Genet. 24 (1972) (Suppl.) 572–585.

    Google Scholar 

  5. Salzano, F. M., Hirschfeld, H. The dynamics of the Gc polymorphism in a Brazilian population. Acta Genet. (Basel) 15 (1965) 116–125.

    Google Scholar 

  6. Spielmann, W., Teixidor, D., Renninger, W., Matznetter, T. Blutgruppen und Lepra bei moçambiquanischen Völkerschaften. Humangenetik 10 (1970) 304–317.

    Google Scholar 

  7. Walter, H., Kellermann, G., Bajatzadeh, M., Krüger, J., Chakravartti, M. R. Hp, Gc, Cp, Tf, Bg and Pi phenotypes in leprosy patients and healthy controls from West Bengal (India). Humangenetik 14 (1972) 314–325.

    Google Scholar 

  8. Nevo, S., Sutton, H. E. Association between response to typhoid vaccination and known genetic markers. Am. J. Hum. Genet. 20 (1968) 461–469.

    Google Scholar 

  9. Nevo, S. Association of typhoid fever and response to vaccination with polymorphic systems in man. In:Peeters, H. (ed.), Prot. Biol. Fluids, Vol. 22, Pergamon Press, Oxford, 1975, pp. 649–653.

    Google Scholar 

  10. Cleve, H. Die Verteilung der Gc-Typen und Gc-Allele bei Kranken mit Diabetes mellitus und chronischer Polyarthritis. Humangenetik 2 (1966) 355–362.

    Google Scholar 

  11. Thymann, M., Dickmeiss, E., Svejgaard, A., Pedersen, C., Bygbjerg, L., Faber, V. AIDS and the Gc protein. Lancet I (1987) 1378.

    Google Scholar 

  12. Nixon, D. F., Eglin, R. P., Westwood, S. A., Werret, D. J., Rizza, C. R. Group-specific component and HIV infection. Lancet II (1987) 39–40.

    Google Scholar 

  13. Constans, J., Smilovici, W., Ducos, J., Robert, J., Boneu, B. Group-specific component and HIV infection. Lancet II (1987) 40.

    Google Scholar 

  14. de Lange, G. G., van Eede, P. H., ten Veen, J. H., Reesink, H. W., Lelie, P. N. Group-specific component and HIV infection. Lancet II (1987) 282–283.

    Google Scholar 

  15. Lefrère, J. J., Rouger, P., Seger, J., Ferrer-le-Coeur, F., Salmon, D., Salmon, C. Group-specific component and HIV infection. Lancet II (1987) 283.

    Google Scholar 

  16. Gilles, K., Louie, L., Newman, B., Crandall, J., King, M.-C. Group-specific component and HIV infection. New Engl. J. Med. 317 (1987) 630–631.

    Google Scholar 

  17. Daiger, S. P., Brewton, G. W., Rios, A. A., Mansell, P. W. A., Reuben, J. M. Group-specific component and HIV infection. New Engl. J. Med. 317 (1987) 631–632.

    Google Scholar 

  18. Schmid, K. Alpha-1-acid glycoprotein. In:Putnam, F. W. (ed.), The plasma proteins. Vol. 1. Acad. Press, New York-London, 1975, pp. 183–228.

    Google Scholar 

  19. Cleve, H., Dencker, H. Quantitative variations of the group-specific component (Gc) and of barium-α2-glycoprotein of human serum in health and disease. In:Peeters, H. (ed.), Prot. Biol. Fluids, vol. 14 (1966) 379–384.

    Google Scholar 

  20. Lebreton, J. P., Joisel, F., Raoult, J. P., Lannuel, B., Rogez, J. P., Humbert, G. Serum concentration of human alpha2HS glycoprotein during the inflammatory process. J. Clin. Invest. 64 (1979) 1118–1129.

    Google Scholar 

  21. McKusick, V. A. Mendelian inheritance in man. Catalogs of autosomal dominant, autosomal recessive, and X-linked phenotypes. 7th ed., The Johns Hopkins University Press, Baltimore-London 1986.

    Google Scholar 

  22. Cleve, H., Patutschnick, W., Nevo, S., Wendt, G. G. Genetic studies on the Gc subtypes. Hum. Genet. 44 (1978) 117–122.

    Google Scholar 

  23. Weidinger, S., Cleve, H., Schwarzfischer, F., Patutschnick, W. The Gc system in paternity examinations, application of Gc subtyping by isoelectricfocusing. In:Hummel, K., Gerchow, J. (eds.), Biomathematical Evidence of Paternity, Springer, Berlin, Heidelberg 1981, pp. 113–121.

    Google Scholar 

  24. Weidinger, S., Schwarzfischer, F., Müller, T., Cleve, H.: Orosomucoid (ORM) subtyping: application to paternity testing. In:Mayr, W. R. (ed.), Advances in Forensic Haemogenetics, Vol. 2, Springer, Berlin, Heidelberg, New York, in press.

  25. Weidinger, S.: Isoelektrische Fokussierung und Printimmunofixation: Ein schnelles Verfahren zur Typisierung des Alpha-2-HS-Glykoproteins. In:Radola, B. J., (ed.), Elektrophorese-Forum '86, Techn. Univ. München 1986, pp. 156–162.

  26. Gürtler, L. G., Eberle, J., Lorbeer, B., Deinhardt, F. Sensitivity and specificity of commercial ELISA kits for screening anti-LAV/HTLV-III. J. Virol. Meth. 15 (1987) 11–23.

    Google Scholar 

  27. Weidinger, S., Müller, T., Schwarzfischer, F., Cleve, H. Three new orosomucoid (ORM) variants revealed by isoelectric focusing and print immunofixation. Hum. Genet. 77 (1987) 286–288.

    Google Scholar 

  28. Cleve, H. Das Vitamin-D-bindende Protein des menschlichen Plasmas. Zur Analyse genetischer Variabilität. Naturwissenschaften 72 (1985) 519–526.

    Google Scholar 

  29. Bowman, B. H. AIDS and the Gc protein. Lancet I (1987) 1377–1378.

    Google Scholar 

  30. Viau, M., Constans, J., Debray, H., Montreuil, J. Isolation and characterization of the O-glycan chain of the human vitamin-D binding protein. Biochem. Biophys. Res. Commun. 117 (1983) 324–331.

    Google Scholar 

  31. Constans, J., Arlet, P., Viau, M., Bouissou, C. Unusual sialilation of the serum DBP associated with the Gc1 allele in alcoholic cirrhosis of the liver. Clin. Chim. Acta 130 (1983) 219–230.

    Google Scholar 

  32. Cleve, H., Patutschnick, W. Neuraminidase treatment reveals sialic acid differences in certain genetic variants of the Gc system (vitamin-D-binding protein). Hum. Genet. 47 (1979) 193–198.

    Google Scholar 

  33. Thymann, M., Hoste, B., Scheffrahn, W., Constans, J., Cleve, H. Unusual sialilation of three different rare genetic variants of serum DBP: Gc 1A17, Gc 1A16, and Gc 1A11. Hum. Genet. 69 (1985) 224–227.

    Google Scholar 

  34. Nakasono, I., Iwasaki, M., Ogata, M., Yoshida, C., Yoshitake, T., Narita, K., Suyama, H., Tomohiro, Y. A new single band variant of the Gc subtypes determined by isoelectric focusing. Hum. Genet. 64 (1983) 184–185.

    Google Scholar 

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Authors and Affiliations

  1. Institut für Anthropologie und Humangenetik der Universität München, Richard-Wagner-Str. 10, D-8000, München 2

    H. Cleve &  S. Weidinger

  2. Max v. Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie der Universität München, Pettenkoferstr. 9a, D-8000, München 2

    L. G. Gürtler &  F. Deinhardt

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  1. H. Cleve
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  2. S. Weidinger
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  3. L. G. Gürtler
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  4. F. Deinhardt
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Cleve, H., Weidinger, S., Gürtler, L.G. et al. AIDS: No association with the genetic systems GC (D-binding protein), ORM (orosomucoid = alpha-1-acid glycoprotein), and A2HS (alpha-2-HS-glycoprotein). Infection 16, 31–35 (1988). https://doi.org/10.1007/BF01646929

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