Summary
The influence of two tetracyclines, lymecycline and doxycycline on leukocyte chemotaxis was investigated in vitro and in vivo. Doxycycline in high concentrations caused a severe depression of both spontaneous and induced migration, an effect which was more pronounced than that caused by lymecycline. Similar results were obtained in experiments on healthy volunteers given recommended dosages of the respective preparations. A corresponding depression of leukocyte chemotaxis was found in some patients given doxycycline as preventive treatment. These findings were discussed with regard to possible negative side-effects of doxycycline in bowel surgery.
Zusammenfassung
Es wurde der Einfluß zweier Tetracycline, des Lymecyclins und des Doxycyclins, auf die Leukozyten-Chemotaxis in vitro und in vivo untersucht. Doxycyclin in hohen Konzentrationen bewirkte eine starke Verminderung der spontanen und induzierten Leukozytenwanderung; die Wirkung war stärker als bei Lymecyclin. Versuche an gesunden Freiwilligen mit gebräuchlichen Dosen der genannten Präparate ergaben gleichartige Befunde. Eine derartige Verringerung der Leukozyten-Chemotaxis fand sich auch bei einigen Patienten nach prophylaktischer Gabe von Doxycyclin. Diese Befunde werden im Hinblick auf mögliche Nebenwirkungen von Doxycyclin in der Abdominalchirurgie diskutiert.
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Gnarpe, H., Belsheim, J. & Persson, S. Tetracycline interference with leukocyte chemotaxis in vitro and in vivo. Infection 6 (Suppl 1), S98–S101 (1978). https://doi.org/10.1007/BF01646076
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DOI: https://doi.org/10.1007/BF01646076