Summary
Tests were done with various antibiotics (ampicillin, carbenicillin, cefazolin, cefotaxime, cephradine, ticarcillin) in order to determine the significance of sputum and pleural concentrations for adequate therapy of bronchopulmonary infections. In a total of 19 chronic bronchitis patients, it was found that the attainable sputum concentrations were rather low and that individual fluctuations were great. No clear connection was evident between dosage and concentration of antibiotics in the sputum. In 17 patients with exudative pleurisy, test data yielded in pleural kinetics largely corresponded with data from animal experiment models. The pleural cavity can be described as a pertial extracellular, extravascular compartment in which the concentration course probably correlates more to the interstitial lung concentrations than to that of the sputum.
Zusammenfassung
In Untersuchungen mit mehreren Antibiotika (Ampicillin, Carbenicillin, Cefazolin, Cefotaxim, Cefradin, Ticarcillin) wurde geprüft, welche Bedeutung Sputum- und Pleurakonzentrationen für die adäquate Therapie von bronchopulmonalen Infektionen haben. Bei insgesamt 19 chronischen Bronchitikern konnte festgestellt werden, daß die erreichbaren Sputumkonzentrationen eher gering waren und stark individuell streuten. Ein klarer Zusammenhang zwischen Antibiotika-Dosierung und Konzentration im Sputum war nicht ersichtlich. Bei 17 Patienten mit exsudativer Pleuritis ergaben sich in der Pleurakinetik Meßwerte, die weitgehend mit den Daten aus tierexperimentellen Modellen übereinstimmten. Der Pleuraraum kann als ein extrazelluläres, extravaskuläres Teilkompartiment bezeichnet werden, in dem der Konzentrationsverlauf wahrscheinlich mehr als im Sputum zu den interstitiellen Lungenkonzentrationen korreliert.
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Lode, H., Gruhlke, G., Hallermann, W. et al. Significance of pleural and sputum concentrations for antibiotic therapy of bronchopulmonary infections. Infection 8 (Suppl 1), S49–S57 (1980). https://doi.org/10.1007/BF01644936
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DOI: https://doi.org/10.1007/BF01644936