Summary
Twelve cases of multiply resistantAcinetobacter calcoaceticus bacteremia occurred in three intensive care units in three different outbreaks. All patients were mechanically ventilated, on broad spectrum antibiotics and had central lines when bacteremia occurred. The sites of primary infection were: abdominal (n=3); respiratory (n=4); central lines (n=4); CNS (n=1). In eight cases the acinetobacter strains were susceptible to ciprofloxacin only. Four other strains were sensitive to amikacin as well. All 11 patients treated with ciprofloxacin alone (seven) or in combination with amikacin (four) fully recovered from the infection. The 12th patient died before antibiotic susceptibility was available. Ciprofloxacin seems to be an excellent therapeutic agent forA. calcoaceticus infections.
Zusammenfassung
Während drei verschiedener Ausbrüche traten in drei Intensivstationen 12 Fälle von Bakteriämie durch multiresistente Stämme vonAcinetobacter calcoaceticus auf. Als die Bakteriämie auftrat, wurden alle diese Patienten künstlich beatmet, erhielten Breitspektrumantibiotika und hatten zentrale Gefäßkatheter. In drei Fällen war die Primärinfektion im Abdomen, in vier Fällen in den Atemwegen lokalisiert, viermal handelte es sich um Katheterinfektionen und einmal um eine ZNS-Infektion. In acht Fällen waren die Acinetobacter-Stämme nur gegen Ciprofloxacin empfindlich. Bei vier Stämmen bestand auch Empfindlichkeit gegen Amikacin. Alle mit Ciprofloxacin allein (sieben) oder in Kombination mit Amikacin (vier) behandelten Patienten erholten sich vollständig von ihrer Infektion. Der 12. Patient starb bevor die Resistenztestung vorlag. Ciprofloxacin ist offensichtlich ein ausgezeichnetes Therapeutikum zur Behandlung von Infektionen durchA. calcoaceticus.
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Leonov, Y., Karpuch, J., Lewinson, G. et al. Ciprofloxacin in the treatment of nosocomial multiply resistant Acinetobacter calcoaceticus bacteremia. Infection 18, 234–236 (1990). https://doi.org/10.1007/BF01643395
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DOI: https://doi.org/10.1007/BF01643395