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Cerebrospinal fluid concentrations of metronidazole, tinidazole and ornidazole in rabbits

Liquorkonzentrationen von Metronidazol, Tinidazol und Ornidazol bei Kaninchen

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Summary

The penetration of metronidazole, tinidazole and ornidazole into the cerebrospinal fluid (CSF) of rabbits was determined using a bioassay based on the antibacterial activity of the drugs. After an intravenous dose of 50 mg, the CSF levels of each drug exceeded previously reported minimum bactericidal concentrations againstBacteroides fragilis. Low serum levels of each drug, produced by intramuscular administration of low doses, resulted in CSF/serum ratios ranging from 0.63–0.73.

Zusammenfassung

Die Penetration von Metronidazol, Tinidazol und Ornidazol in den Liquor cerebrospinalis von Kaninchen wurde mittels eines auf der antibakteriellen Aktivität der Substanzen basierenden Bioassay bestimmt. Nach einer intravenösen Dosis von 50 mg lagen die Liquorspiegel jeder der Substanzen über den kürzlich als minimale bakterizide Konzentrationen gegenBacteroides fragilis mitgeteilten Werte. Durch intramuskuläre Applikation von kleinen Dosen erzielte niedrige Serumspiegel ergaben für jede der Substanzen Liquor/Serum Relationen zwischen 0,63–0,73.

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Authors and Affiliations

  1. Department of Serology and Bacteriology, University of Helsinki, Haartmaninkatu 3, 00290, Helsinki 29, Finland

    A. M. M. Jokipii &  L. Jokipii

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  1. A. M. M. Jokipii
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  2. L. Jokipii
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Jokipii, A.M.M., Jokipii, L. Cerebrospinal fluid concentrations of metronidazole, tinidazole and ornidazole in rabbits. Infection 8, 101–103 (1980). https://doi.org/10.1007/BF01641471

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  • DOI: https://doi.org/10.1007/BF01641471

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