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Diagnosis and treatment of chlamydial venereal disease

Diagnose und Behandlung der venerischen Chlamydieninfektionen

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Summary

We examined patients attending an STD clinic (Department of Dermatology, Lasarettet, Lund).Chlamydia trachomatis was demonstrated in 26% of 2021 male patients by culture from the urethra (using cyclo-heximide-treated McCoy cells). The corresponding figure forNeisseria gonorrhoeae was 15%. Both organisms were found in 5% of the patients. In women, culture from the cervix demonstratedC. trachomatis in 16% of 1039 patients.N. gonorrhoeae was found in 14%, and both organisms in 4% of the patients. Men with chlamydial urethritis were more frequently found to have a watery discharge than those with gonococcal urethritis. They also had fewer leucocytes in smears from the urethra. Treatment with different tetracyclines gives good therapeutic results in both men and women infected withC. trachomatis. In contact-tracing, 53% of 95 male partners and 65% of 103 female partners were found to harbourC. trachomatis. About 50% of these contacts were free of symptoms. This indicates the importance of contact-tracing in genital chlamydial infection.

Zusammenfassung

Wir untersuchten Patienten einer venerologischen Klinik (Department of Dermatology, Lasarettet, Lund). Bei 26% von 2021 männlichen Patienten wurdeChlamydia trachomatis aus der Urethra (unter Verwendung von Cycloheximidbehandelten McCoy-Zellen) kulturell nachgewiesen. FürNeisseria gonorrhoeae ergab sich ein entsprechender Prozentsatz von 15. Bei 5% der Patienten fanden sich beide Erreger. 1039 Frauen wiesen zu 16%C. trachomatis in Kulturen aus der Cervix auf.N. gonorrhoeae fand sich bei 14% und beide Erreger bei 4% der Fälle. Bei Männern mit Chlamydienurethritis trat häufiger eine wäßrige Absonderung aus der Urethra auf als bei Männern mit Gonokokkenurethritis; die Leukozytenzahl in den Urethraabstrichen war außerdem geringer. Die therapeutischen Ergebnisse der Behandlung vonC. trachomatis-Infektionen mit verschiedenen Tetrazyklinen sind bei Frauen wie auch bei Männern gut. Bei der Suche nach der Kontaktperson wurden 53% von 95 männlichen und 65% von 103 weiblichen Partnern alsC. trachomatis-Träger identifiziert. Etwa 50% der Kontaktpersonen waren asymptomatisch, woraus die Bedeutung der Kontaktsuche bei genitalen Chlamydieninfektionen klar zu erkennen ist.

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Thelin, I. Diagnosis and treatment of chlamydial venereal disease. Infection 10 (Suppl 1), S53–S56 (1982). https://doi.org/10.1007/BF01640715

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