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Pressure measurements and histological investigations after subcutaneous implantation of diffusion chambers in rabbits

Druckmessungen und histologische Untersuchungen bei subkutan implantierten Diffusionskammern in Kaninchen

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Summary

In separate experiments conducted in rabbits the pressure was measured in a subcutaneously implanted diffusion chamber system for collecting interstitial fluid, and a histological examination was made of the surrounding tissue. Three days after implantation the pressure was negative in all animals (- 4.23±2.5 mmHg). The diffusion chambers were well tolerated in tissue with minimal cell reaction. The lumen of the chambers remained free of cellular elements for up to 30 days.

Zusammenfassung

In getrennten Versuchen wurden bei Kaninchen Druckmessungen an einem subkutan implantierten Diffusionskammersystem zur Gewinnung interstitieller Flüssigkeit sowie histologische Untersuchungen des umgebenden Gewebes durchgeführt. Drei Tage nach Implantation war der Druck mit einem Mittelwert von - 4,23±2,5 mmHg bei allen Tieren negativ. Die Diffusionskammern zeigten eine gute Gewebsverträglichkeit bei minimaler Zellreaktion. Das Kammerlumen war bis zum 30. Tag frei von zellulären Elementen.

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Authors and Affiliations

  1. Sandoz Forschungsinstitut, Brunner Straße 59, A-1235, Vienna, Austria

    G. Laber,  H. Obenaus &  H. Walzl

Authors
  1. G. Laber
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  2. H. Obenaus
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  3. H. Walzl
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Laber, G., Obenaus, H. & Walzl, H. Pressure measurements and histological investigations after subcutaneous implantation of diffusion chambers in rabbits. Infection 8, 187–189 (1980). https://doi.org/10.1007/BF01639030

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  • DOI: https://doi.org/10.1007/BF01639030

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