Abstract
An implantable catheter flow sensor with legs for measuring the breathing characteristics of disease-model animals was developed. The unique feature of this sensor is the use of legs to fix the sensor to the inside wall surface of the air passage without preventing ciliary motion. Differently shaped legs were fabricated by application of a heat shrinkable tube. Prototype sensors was inserted into tubes with inner diameters ranging from 2.4 to 2.7 mm and successfully anchored to the inside surface by the legs. An evaluation of the relationship between the sensor output and the flow rate demonstrated that the sensor output against the flow rate obeyed King’s law. The sensor output variation with different inner tube diameters was suppressed to less than 3 %. The developed catheter flow sensor was applied to the breathing measurements in the rat and the rabbit. The breathing waveform obtained from the flow sensor in the rat coincidented to the mechanism of breathing. The sensor was implated into the rabbit bronchus by using a fiberscope, and the breathing characteristics in the bronchus 3 days after implant were successfully measured.
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This research was supported by The Canon Foundation and JSPS KAKENHI Grant Number 26286034, Japan.
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Shikida, M., Matsuyama, T., Yamada, T. et al. Development of implantable catheter flow sensor into inside of bronchi for laboratory animal. Microsyst Technol 23, 175–185 (2017). https://doi.org/10.1007/s00542-015-2663-8
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DOI: https://doi.org/10.1007/s00542-015-2663-8