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Gentamicin therapy of severe infections

Gentamicintherapie bei schweren Infektionen

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Summary

Gentamicin was administered to 32 patients with severe infections due to gram-negative bacilli, 17 caused byPseudomonas aeruginosa. Fourteen of the 32 patients had major underlying diseases, and three patients had been unsuccessfully treated with carbenicillin or cephalothin prior to gentamicin therapy.

Thirteen of the 17 patients with septicemia were cured, six of eight patients with respiratory tract infections and four of seven patients with wound infections. In addition to gentamicin, six patients who were cured also received carbenicillin, cephalothin or ampicillin. Therapeutic failure could be attributed to major underlying noninfectious diseases, undrained abscesses, profound granulocytopenia, pronounced shock or superinfection.

Gentamicin was well tolerated. Two patients developed transient azotemia and one patient superinfection withCandida species.

Gentamicin is a valuable drug in the therapy of severe gram-negative infections.

Zusammenfassung

Zweiunddreißig Patienten mit schweren, durch gramnegative Bakterien verursachten Infektionen wurden mit Gentamicin behandelt, 17 Fälle davon wurden durch Ps. aeruginosa verursacht. Vierzehn der 32 Patienten hatten schwere Grundleiden, und drei Patienten wurden ohne Erfolg mit Carbenicillin oder Cephalotin vorbehandelt.

Dreizehn der 17 Patienten mit Sepsis wurden geheilt, sechs von acht Patienten mit Infektionen der Atemwege und vier von sieben Patienten mit Wundinfektionen. Zusätzlich zu Gentamicin erhielten sechs der Patienten auch Carbenicillin, Cephalotin oder Ampicillin. Therapieversager traten bei den schweren Grundleiden, bei einem nicht drainierten Abszeß, bei einer Granulozytopenie, bei einem fortgeschrittenen Schock und bei Superinfektionen auf.

Das Gentamicin wurde gut vertragen. Bei zwei Patienten entwickelte sich eine Harnstofferhöhung und bei einem eine Superinfektion mit Candida.

Gentamicin ist als ein wertvolles Therapeutikum zur Behandlung von schweren gramnegativen Erregern verursachten Infektionen anzusehen.

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Authors and Affiliations

  1. From the Medical Department B, University of Bergen, Bergen, Norway

    C. O. Solberg & A. Schreiner

  2. Haukeland Hospital, 5000, Bergen, Norway

    C. O. Solberg

Authors
  1. C. O. Solberg
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  2. A. Schreiner
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Solberg, C.O., Schreiner, A. Gentamicin therapy of severe infections. Infection 1, 105–109 (1973). https://doi.org/10.1007/BF01638484

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  • DOI: https://doi.org/10.1007/BF01638484

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