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Zur Problematik der serodiagnostischen Untersuchungen bei Candida-Infektionen

Problems in the serological diagnosis of Candida infections

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Zusammenfassung

Um Aufschluß über die humorale Antikörperbildung gegenCandida albicans bei Organ-, Haut- und Schleimhaut-Candidamykose und verschiedenen Hauterkrankungen mit negativerCandida-Kultur zu erhalten, wurde parallel nach dem Auftreten agglutinierender, komplementbindender und präzipitierender Antikörper gegenCandida albicans-Vollantigene und gegen Antigenfraktionen gefahndet. Anhand von bisher 58 so geprüften Patientenseren ließ sich in den Titerhöhen bei den einzelnen Reaktionen nur teilweise Übereinstimmung finden. Unter den gegebenen Verhältnissen erscheint es nötig, vorerst stets zwei der vier aufgeführten Seroreaktionen parallel durchzuführen und die Titerdynamik in Abständen von 2 bis 4 Wochen zu verfolgen.

Summary

The appearance of serum antibodies against Candida albicans was examined in patients suffering from superficial and systemic candidamycosis as well as in patients suffering from cutaneous disorders without Candida infection. Parallel studies were performed in order to demonstrate agglutinating, complement-fixing and precipitating antibodies against whole antigens and antigenic fractions of Candida albicans.

On the basis of 58 investigated serum specimens it was found that Candida antibodies in significant titers developed mainly in patients suffering from Candida infections. The titers obtained in the various reactions showed, however, only a partial concordance. The possible reasons for this are discussed.

Under the present conditions it appears advisable to use at least two different serum reactions simultaneously in the study of Candida antibodies and to observe the course of titers in intervals of 2–3 weeks.

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Authors and Affiliations

  1. Aus der Klinik für Haut- und Geschlechtskrankheiten der „Ignac Semmelweis“-Medizinischen Universität, Budapest, Germany

    I. Török, H. P. R. Seeliger & F. Keller

  2. dem Institut für Hygiene und Mikrobiologie der Universität, Würzburg, Germany

    I. Török, H. P. R. Seeliger & F. Keller

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  1. I. Török
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  2. H. P. R. Seeliger
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  3. F. Keller
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Török, I., Seeliger, H.P.R. & Keller, F. Zur Problematik der serodiagnostischen Untersuchungen bei Candida-Infektionen. Infection 1, 82–87 (1973). https://doi.org/10.1007/BF01638480

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