Summary
Results are presented indicating that Ristocetin aggregated normal platelet but failed to cause platelet aggregation in 11 out of 15 patients withv. Willebrand's disease.
No correlations were found between Ristocetin-induced platelet aggregation and bleeding time or platelet adhesiveness. On the contrary a correlation existed between Ristocetin aggregation and factor VIII antigen and activity, in the examinedv. Willebrand patients.
Zusammenfassung
Die Verfasser untersuchten an 20 gesunden Personen und 15 Patienten mit M.v.Willebrand die Beziehungen zwischen Ristocetin-induzierter Plättchenaggregation und den Antigen- und Aktivitätswerten bei genannter Krankheit.
Die Kriterien für die Diagnose des M.v. Willebrand waren genau festgelegt.
Ristocetin aggregierte normale Plättchen, aber in 11 von 15 Patienten mit M.v. Willebrand gelang die Aggregation nicht. Es wurde keine Beziehung zwischen Ristocetin-induzierter Plättchenaggregation und Blutungszeit oder Plättchenklebbarkeit festgestellt.
Aber es bestand eine Beziehung zwischen Ristocetin-Aggregation und den Antigen- und Aktivitätswerten von Faktor VIII bei denv. Willebrand-Patienten.
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Barbui, T., Battista, R. & Dini, E. Relationship between Ristocetin-induced platelet aggregation and factor VIII (activity and antigen) in v. Willebrand's disease. Blut 29, 260–264 (1974). https://doi.org/10.1007/BF01635547
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DOI: https://doi.org/10.1007/BF01635547