Skip to main content
SpringerLink
Log in

Retrospective approach to explain growth retardation and urolithiasis in a child with long-term nutritional acid loading

Wachstumsverminderung und Harnsteine bei einem Kind mit langwährender alimentärer Säurebelastung, eine retrospektive Betrachtung

  • Originalarbeiten
  • Published:
Zeitschrift für Ernährungswissenschaft Aims and scope Submit manuscript

Summary

An infant with phenylketonuria unintentionally received a highly acidic low phenylalanine diet for 29 months. Temporary growth retardation and urolithiasis were observed, probably as direct effects of chronic acid loading. Caries at the age of 6 years may be a late consequence. This case report shows that chronic dietary acid load may cause serious side effects.

Zusammenfassung

Ein Säugling mit Phenylketonurie erhielt unbeabsichtigt für insgesamt 29 Monate eine phenylalaninarme Diät mit hoher alimentärer Säurelast. Eine vorübergehende Wachstumsretardierung und die Entwicklung von Harnsteinen dürften direkte Folgen, eine Karies im Alter von 6 Jahren möglicherweise eine langfristige Konsequenz der chronischen Säurebelastung gewesen sein. Das Beispiel dieser Krankengeschichte zeigt, daß eine chronische alimentäre Säurebelastung ernsthafte klinische Folgen haben kann.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bach D, Hesse A (1991) Normalwerte lithogener und inhibitorischer Substanzen im Urin gesunder Kinder. Urologie Nephrologie 3:209–217

    Google Scholar 

  2. Bickel H, Schmidt H, Schürrle L (1973) Dietary treatment of inborn errors of amino acid and carbohydrate metabolism. Bibl Nutr Diet 18:181–201

    Google Scholar 

  3. Fomon SJ (1974) Infant nutrition, 2nd ed Saunders, Philadelphia

    Google Scholar 

  4. Edelman CM, Boichis H, Rodriguez-Soriano J, Stark H (1967) The renal response of children to acute ammonium chloride acidosis. Pediatr Res 1:452–460

    Article  Google Scholar 

  5. Heird WC, Dell RB, Driscoll JM, Grebin B, Winters RW (1972) Metabolic acidosis resulting from intravenous alimentation mixtures containing synthetic amino acids. New Engl J Med 287:943–948

    Article  CAS  Google Scholar 

  6. Herzberg GZ, Fivush BA, Kinsman SL, Gearhart JP (1990) Urolithiasis associated with the ketonic diet. J Pediatr 117:743–745

    Article  CAS  Google Scholar 

  7. Kahn B, Straub CP, Robbins PJ, Wellmann HN, Seltzer RA, Telles NC (1969) Retention of radiostronthium, stronthium, calcium and phosphorus by infants. Pediatrics 43:651–756

    CAS  Google Scholar 

  8. Kalhoff H, Manz F, Diekmann L, Stock GJ (1990) Suboptimal mineral composition of cow's milk formulas: a risk factor for the development of late metabolic acidosis. Acta Paediatr Scand 79:743–749

    Article  CAS  Google Scholar 

  9. Kildeberg P (1964) Disturbances of hydrogen ion balance occurring in premature infants. II. Late metabolic acidosis. Acta Paediatr Scand 53:517–526

    Article  CAS  Google Scholar 

  10. Klohn M, Bolle JF, Reverdin NP, Susini A, Baud C-A, Graber P (1986) Ammonium urate urinary stones. Urol Res 14:315–318

    Article  CAS  Google Scholar 

  11. Lindquist B, Svenningsen NW (1983) Acid-base homeostasis of low-birth-weight and full-term infants in early life. J Pediatr Gastroenterol Nutr 2, Suppl 1:S99-S107

    Article  Google Scholar 

  12. Manz F, Schmidt H, Schärer K, Bickel H (1977) Acid-base status in dietary phenylketonuria. Pediatr Res 11:1084–1087

    Article  CAS  Google Scholar 

  13. Manz F, Vecsei P, Wesch H (1984) Renale Säureausscheidung und renale Molenlast bei gesunden Kindern und Erwachsenen. Monatsschr Kinderheilkd 132:163–167

    CAS  Google Scholar 

  14. Schneider HJ (1985) Epidemiology of urolithiasis. In: Schneider HJ (ed) Urolithiasis: etiology — diagnosis. Springer, Berlin, pp 137–184

    Chapter  Google Scholar 

  15. Tanner JM, Whitehouse RH, Takaishi M (1966) Standards from birth to maturity for height, weight, height velocity and weight velocity: British children, 1965. Part II. Arch Dis Child 41:613–635

    Article  CAS  Google Scholar 

  16. Wissenschaftliche Tabellen Geigy (1977) Teilband Körperflüssigkeiten, 8 Aufl. Ciba-Geigy, Basel

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Forschungsinstitut für Kinderernährung, Dortmund

    F. Manz

  2. Universitäts-Kinderklinik Heidelberg, Deutschland

    H. Schmidt

Authors
  1. F. Manz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Manz, F., Schmidt, H. Retrospective approach to explain growth retardation and urolithiasis in a child with long-term nutritional acid loading. Z Ernährungswiss 31, 121–129 (1992). https://doi.org/10.1007/BF01623070

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01623070

Key words

Schlüsselwörter

Search

Navigation