Abstract
We report a signet-ring stromal tumour found in the ovary of a 50-year-old woman. The solid tumour was composed of spindle and round cells which stained with vimentin and some round cells were vacuolated and had the appearance of signet-ring cells. The vacuoles were negative with periodic acid-Schiff, with and without diastase digestion, with alcian blue, Sudan III, alpha-1-antitrypsin and alpha-fetoprotein stains. Ultrastructurally, they were membrane bound and contained scanty flocculent material. Some neoplastic cells contained intracytoplasmic eosinophilic globules which were positive with alpha-1-antitrypsin. Signet-ring stromal tumour is a benign, morphologically distinctive type of ovarian stromal tumour, which may present problems in differential diagnosis with other stromal and non stromal ovarian neoplasms.
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Suárez, A., Palacios, J., Burgos, E. et al. Signet-ring stromal tumor of the ovary: A histochemical, immunohistochemical and ultrastructural study. Vichows Archiv A Pathol Anat 422, 333–336 (1993). https://doi.org/10.1007/BF01608344
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DOI: https://doi.org/10.1007/BF01608344