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Ovarian Sclerosing Stromal Tumor

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Soft Tissue Tumors

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Abstract

Ovarian sclerosing stromal tumor is a benign neoplasm classified among the pure stromal tumors (along with ovarian fibroma, thecoma, Leydig cell tumor, and steroid cell tumor), which in turn belong to the family of sex cord-stromal tumors (which include pure sex cord tumors and mixed sex cord-stromal tumors).

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Notes

  1. 1.

    SMA: smooth muscle actin.

  2. 2.

    EMA: epithelial membrane antigen.

  3. 3.

    GLI2: GLI family zinc finger 2 encodes a protein belonging to the C2H2-type zinc finger protein subclass of the Gli family, which includes transcription factors that bind DNA through zinc finger motifs. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and act as potent oncogenes in the embryonal carcinoma cell. GLI2 protein localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression.

Suggested Readings

  • Kim et al (2020) Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary. Nat Commun 11(1):44

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  • Park et al (2017) Clinicopathological characteristics of ovarian sclerosing stromal tumor with an emphasis on TFE3 overexpression. Anticancer Res 37(10):5441–5447

    CAS  PubMed  Google Scholar 

  • Young et al (2018) Ovarian sex cord-stromal tumours and their mimics. Pathology 50(1):5–15

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  • Zhao et al (2018) The value of MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary: emphasis on diffusion-weighted MR imaging. J Ovarian Res 11(1):73

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Authors and Affiliations

  1. Department of Surgery Oncology and Gastroenterology, University of Padova, Padova, Italy

    Simone Mocellin

  2. Melanoma and Soft Tissue Sarcoma Unit, Istituto Oncologico Veneto (IOV-IRCCS) of Padova, Padova, Italy

    Simone Mocellin

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  1. Simone Mocellin
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Correspondence to Simone Mocellin .

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Cite this chapter

Mocellin, S. (2021). Ovarian Sclerosing Stromal Tumor. In: Soft Tissue Tumors . Springer, Cham. https://doi.org/10.1007/978-3-030-58710-9_195

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  • DOI: https://doi.org/10.1007/978-3-030-58710-9_195

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-58709-3

  • Online ISBN: 978-3-030-58710-9

  • eBook Packages: MedicineMedicine (R0)

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