Abstract
Fifteen cases of generalized peripheral T-cell non-Hodgkin's lymphoma in baboons were phenotyped immunologically and morphologically. Using the updated Kiel classification the cases included low-grade and high-grade lymphomas and low-grade lymphomas that had transformed into high-grade lymphomas. In the low-grade group there were seven cases of lymphocytic type, partly corresponding to chronic lymphocytic leukaemia of T type and to T-zone lymphoma in man. In addition there were four cases of prolymphocytic-lymphocytic type, which show large nodules (“proliferation centres”) and which have no equivalent in the Kiel classification. In four cases there was a progression to an immunoblastic lymphoma and in one case to a large cell anaplastic lymphoma. In addition, three cases of large cell anaplastic lymphoma without a low-grade component were found. Both the immunoblastic lymphomas and the large cell anaplastic lymphomas corresponded well with the same types in the Kiel classification. The cases of large cell anaplastic lymphoma were also CD30 positive. Most of these lymphomas were CD4 positive, but there were rare cases that were either CD8 positive, showed both CD4 and CD8 positivity or had lost both antigens. Antigens associated with cell activation were often revealed. All but one baboon had antibodies in the blood against the retrovirus STLV-1 (simian T-cell leukaemia virus 1), which is very similar to human T-cell leukaemia virus 1 (HTLV-1) in man. Despite this virological resemblance, the morphology of these T-cell lymphomas does not resemble that of the HTLV-1-positive Japanese T-cell lymphomas but is like that of the HTLV-1-negative European cases.
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References
Anagnostopoulos J, Hummel M, Kaudewitz P, Herbst M, Braun-Falco O, Stein H (1990) Detection of HTLV-1 proviral sequences in CD30-positive large cell cutaneous T-cell lymphomas. Am J Pathol 137:1317–1322
Clark EA, Draves KE (1987) Activation of macaque T-cells and B-cells with agonistic monoclonal antibodies. Eur J Immunol 17:1799–1805
Doi S, Nasu K, Arita Y, Tanabe S, Matsuyama F, Kamesaki H, Fukuhara S, Nishikori M, Miwa H, Kita K, Hatanaka M, Uchino M (1989) Immunohistochemical analysis of peripheral T-cell lymphoma in Japanese patients. Am J Clin Pathol 91:152–158
Gallo RC, Prem SS, Blattner WA, Wong-Staal F, Popovic M (1984) T-cell malignancies and human T-cell leukemia virus. Semin Oncol 11:12–17
Gérard-Marchant R, Hamlin I, Lennert K, Rilke F, Stansfeld AG, Unnik JAM van (1974) Classification of non-Hodgkin's lymphomas (letter). Lancet II:406–408
Indzhiia LV, Yakovleva LA, Chicobava MG, Valentine MA, Lapin BA, Clark EA (1990) Non-Hodgkin's malignant lymphomas of primates. Immunological approaches to T-cell NHL (in Russian). Vestn Akad Med Nauk SSSR 9:21–27
Indzhiia LV, Yakovleva LA, Licciardi KA, Chicobava MG, Klotz IN, Terres R, Indzhiia VO, Lapin BA, Overbaugh J, Valentine MA (in press) Baboon T-cell lymphomas expressing the B-cell-associated surface proteins CD40 and Bgp95. J Clin Immunol
Johnstone A, Thorpe R (1982) Immunochemistry in practice, 2nd edn. Blackwell, London, pp 276–283
Krayewski AS, Myskow MW, Cachin PG, Salter DM, Sheeham DM, Sheeham T, Dewar AE (1988) T-cell lymphoma: morphology, immunophenotype, and clinical features. Histopathology 13:19–41
Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage 14. Nature 227:680
Lapin BA (1985) Hematopoietic diseases in non-human primates. In: Deinhardt F (ed) Proceedings of the XIIth Symposium for Comparative Research of Leukemia and Related Diseases. Hamburg, pp 277–296
Lapin BA (1988) Baboon lymphoma viruses. In: Darai G (ed) Virus diseases in laboratory and captive animals. Martinus Nijhoff, Boston, pp 135–151
Lapin BA, Yakovleva LA, Agrba VZ, Indzhiia LV, Voevodin AF (1980) Haemoblastosis of primates (in Russian). Medzis, Moscow
Lennert K, Feller AC (1992) Histopathology of non-Hodgkin's lymphomas. Springer, Berlin Heidelberg New York
Lennert K, Mohri N (1978) Histopathology and diagnosis of non-Hodgkin's lymphomas. In: Lennert K (ed) Malignant lymphomas other than Hodgkin's disease. Springer, Berlin Heidelberg New York, pp 111–469
Lennert K, Kikuchi M, Sato E, Suchi E, Stansfeld AG, Feller AC (1985) HTLV-positive and -negative T-cell lymphomas. Morphological and immunohistochemical differences between European and HTLV-positive Japanese T-cell lymphomas. Int J Cancer 35:65–72
Liang GZ, Zhuang HG, Li WC, Guo RZ (1986) T-cell lymphoma: a morphological, histochemical and immunological study of nine Chinese cases. Histopathology 10:1035–1046
Miyoshi I, Kabonishi I, Yoshimoto S, Akadi T, Ohisuki Y, Shirachi Y (1981) Type C virus particles in a cord T cell line derived by cocultivating normal human cord leucocytes and human leukemic T cells. Nature 294:770–771
Picker LJ, Weiss LM, Medeiros LJ, Wood OS, Warnke RA (1987) Immunophenotypic criteria for the diagnoses of non-Hodgkin's lymphomas. Am J Pathol 128:181–201
Poiesz BJ, Ruscetti FW, Garder AF, Bann PA, Mina JD, Gallo RC (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T cell lymphoma. Proc Natl Acad Sci USA 77:7415–7419
Popovic M, Sarin PS, Robert-Gurroff M, Kalyanaraman VS, Mann D, Minowada J, Gallo RC (1983) Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 219:856–859
Ramsay AD, Smith WJ, Earl HM, Souhami RL, Isaacson PG (1987) T-cell lymphomas in adults: a clinicopathological study of eighteen cases. J Pathol 152:63–76
Saxinger WC, Lange-Wantzin G, Thomsen K, Lapin BA, Yakovleva LA, Li YW, Guo HG, Robert-Guroff M, Blattner W, Ito Y, Gallo RC (1984) Human T-cell leukemia virus: a diverse family of related exogenous retroviruses of human and old world primates. In: Gallo RC, Essex ME, Gross L (eds) Human T-cell leukemia/lymphoma viruses. Cold Spring Harbor Laboratory, New York, pp 323–330
Schwartz JE, Grogan TM, Hicks M (1984) Pseudonodular T-cell lymphoblastic lymphoma. Am J Med 77:947–949
Stansfeld AG, Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewska O, Noël H, Rilke F, Sundstrom C, Unnik JAM van, Wright DH (1988) Updated Kiel classification for lymphomas. Lancet I:292–293, 603
Stein H, Mason DY, Gerdes J, O'Connor N, Wainscoat J, Pallesen G, Gatter K, Falini B, Delsol G, Lemke H, Schwarting R, Lennert K (1985) The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue. Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848–858
Suchi T, Lennert K, Tu LY, Kikuchi M, Sato E, Stansfeld AG, Feller AC (1987) Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification. J Clin Pathol 40:995–1015
Van der Valk P, Willemze R, Meijer CJL (1986) Peripheral T-cell lymphomas: a clinicopathological and immunological study of 10 cases. Histopathology 10:235–249
Voevodin AF, Lapin BA, Yakovleva LA, Ponomareva TI, Oganyan TB, Razmadze EN (1985) Antibodies reacting with human T-lymphotropic retrovirus (HTLV-1) or related antigens in lymphomatous and healthy hamadryas baboons. Int J Cancer 36:579–584
Voevodin AF, Lapin BA, Tatosyan AG, Hirsh I (1987) Markers of HTLV-I-related virus in hamadryas baboon lymphoma. In: Neth R, Gallo RC, Greaves MF, Kabisch H (eds) Modern trends in human leukemia res. VII. Haematology and blood transfusion, 31. Springer, Berlin Heidelberg New York, pp 392–394
Watanabe S (1986) Pathology of peripheral T-cell lymphomas and leukemias. Hematol Oncol 4:45–58
Watanabe S, Mukai K, Shimoyama M (1988) Peripheral T-cell lymphoma. Cancer Metastasis Rev 7:243–261
Yakovleva LA, Lapin BA, Bukaeva IA, Indzhiia LV (1985) Differential diagnostic differences between primate B- and T-cell non-Hodgkin's malignant lymphomas. In: Deinhardt F (ed) Proceedings of the XIIth Symposium for Comparative Research on Leukemia and Related Diseases. Hamburg, pp 164–172
Yakovleva LA, Voevodin AF, Bukaeva IA, Indzhiia LV (1986) Cytological variations of malignant lymphomas and intensity of the antibody response to B- and T-lymphotropic viruses in the hamadryas baboons. Primary localized haematopoietic tissue tumors of the non-human primates and tumor generalization (in Russian). In: Lapin BA (ed) Alashara, Sukhumi, pp 32–36
Yakovleva LA, Bukaeva IA, Indzhiia LV (1987) Working classification of non-Hodgkin's malignant lymphomas (NHL's) in baboons at the Sukhumi monkey colony (in Russian). Vestn Akad Med Nauk SSSR 10:28–32
Yakovleva LA, Bukaeva IA, Lapin BA (1990) Non-Hodgkin's malignant lymphomas of follicular germinal center cells type in the baboons of the high risk stock (in Russian). Arch Pathol 52:15–19
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Yakovleva, L.A., Lennert, K., Chikobava, M.G. et al. Morphological characteristics of malignant T-cell lymphomas in baboons. Vichows Archiv A Pathol Anat 422, 109–120 (1993). https://doi.org/10.1007/BF01607162
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DOI: https://doi.org/10.1007/BF01607162