Summary
It was found that spiperone and pimozide in doses which themselves do not influence the flexor reflex of the hind limb of the spinal rat inhibit stimulation of this reflex induced by serotoninomimetic drugs (LSD and fenfluramine). Higher doses of spiperone depress the flexor reflex and inhibit the stimulating effect of clonidine. Pimozide has no such effect. Haloperidol in doses which do not influence the action of LSD and fenfluramine produces a depression of the flexor reflex and antagonizes the action of clonidine. Our findings indicate that, irrespective of their antidopamine action, spiperone has a central antiserotonin effect and an antinoradrenaline one, pimozide—an antiserotonin one and haloperidol—an antinoradrenaline one.
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Andén, N.-E., Butcher, S. G., Corrodi, H., Fuxe, K., Ungerstedt, U. Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur. J. Pharmacol.11, 303–314 (1970 a).
Andén, N.-E., Corrodi, H., Fuxe, K., Hökfelt, T., Rydlin, C., Swensson, T. Evidence for a central noradrenaline receptor stimulation by clonidine. Science9, 513–523 (1970 b).
Bingham, W. G., Ruffolo, R., Goodman, J. H., Knofel, J., Friedman, S. Norepinephrine and dopamine levels in normal dog and monkey spinal cord. Life Sci.16, 1521–1526 (1975).
Commissiong, J. W., Sedgwick, E. M. Dopamine and noradrenaline in humany spinal cord. The Lancet1, 347 (1975).
Heal, D. J., Green, A. R., Boullin, D. J., Grahame-Smith, D. G. Single and repeated administration of neuroleptic drugs to rats: Effect on striatal dopamine-sensitive adenylate cyclase and locomotor activity produced by tranylcypromine and L-tryptophan or L-dopa. Psychopharmacology49, 287–300 (1976).
Jacobs, B. L. Effect of two dopamine receptor blockers on a serotoninmediated behavioral syndrome in rats. Eur. J. Pharmac.27, 363–366 (1974).
Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L. Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? Arzneim.-Forsch.15, 104–117 (1965).
Magnusson, T. Effect of chronic transection on dopamine, noradrenaline and 5-hydroxytryptamine in the rat spinal cord. Naunyn-Schmiedeberg's Arch. Pharmacol.278, 13–22 (1973).
Maj, J., Palider, W., Baran, L. The effect of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor. J. Neural Transm.38, 131–147 (1976).
Maj, J., Palider, W., Rawłów, A. The influence of mescaline on the flexor reflex of the hind limb of the spinal rat. J. Pharm. Pharmac.19, 177–178 (1977).
Maj, J., Baran, L., Bigajska, K., Rogóż, Z., Skuza, G.: The effect of neuroleptics on the central action of 5-hydroxytryptophan. Pol. J. Pharmacol. Pharm. (in press, 1978).
Maj, J., Sowińska, H., Baran, L., Gancarczyk, L., Rawłów, A.: The central antiserotonergic action of mianserin. Psychopharmacology (in press, 1978).
Niemegeers, C. J. E., Lenaerts, F. M., Artois, K. S. K., Janssen, P. A. J. Interaction of drugs with apomorphine, tryptamine and norepinephrine. A new “in vivo” approach: the ANT-test in rats. Arch. int. Pharmacodyn.227, 238–253 (1977).
Palider, W., Rawłów, A. Effect of serotonin uptake blocking agents on the flexor reflex of hind limb of the spinal rat. Pol. J. Pharmacol. Pharm.29, 367–376 (1977).
Reid, J. L., Zivin, J. A., Foppen, F. H., Kopin, I. J. Catecholamine neurotransmitters and synthetic enzymes in the spinal cord. Life Sci.16, 975–984 (1975).
Zivin, J. A., Reid, J. L., Saavedra, J. M., Kopin, I. J. Quantitative localization of biogenic amines in the spinal cord. Brain Res.99, 293–301 (1975).
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Maj, J., Palider, W. & Rawłów, A. The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat. J. Neural Transmission 43, 113–120 (1978). https://doi.org/10.1007/BF01579070
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DOI: https://doi.org/10.1007/BF01579070