Abstract
The search for Cγ allotypes as defined by the markers common to domestic rabbits (Oryctolagus) was extended to additional lagomorphs of the familiesLeporidae andOchotonidae. None of theOchotona sera obtained from Afghanistan and Iran (Ochotona rufescens) exhibited the d11, d12, or e14 allotypes. The e15 marker was detected only by radioimmune binding assays. Comparative inhibition of binding assays revealed similarities with other lagomorphs with respect to the e15i determinant. As in some variants of hare e15 markers, the e15j determinant is absent inOchotona. The results provided a revised phylogenetic scheme for the evolution of the Cγ gene on the basis of the e-series allotypes.
Similar content being viewed by others
References
Aggarwal, S. and Mandy, W.J.: Lagomorph IgG hinge region: allotype associated amino acid sequence variations.Immunochemistry 13:215–220, 1976
Appella, E., Chersi, R., Mage, R., and Dubiski, S.: Structural basis of the A14 and A15 allotypic specificities in rabbit immunoglobulin G.Proc. Natl. Acad. Sci. U.S.A. 68:1341–1345, 1971
Avrameas, S. and Ternynck, T.: Biologically active water-insoluble protein polymers. I. Their use for isolation of antigens and antibodies.J. Biol. Chem. 242:1651–1659, 1967
Axen, R., Porath, J., and Ernback, S.: Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides.Nature 214:1302–1304, 1967
Dubiski, S.: Immunochemistry and genetics of a “new” allotypic specificity A 14e of rabbitγG immunoglobulins: recombination in somatic cells.J. Immunol. 103:120–128, 1969
Dubiski, S.: Does antibody synthesis involve somatic recombination?Protides Biol. Fluids 17:117–124, 1970
Greenwood, F.C., Hunter, W.M., and Glover, J.S.: The preparation of131I-labelled human growth hormone of high specific radioactivity.Biochem. J. 89:114–116, 1963
Kindt, T.J.: Rabbit immunoglobulin allotypes: structure, immunology and genetics.Adv. Immunol. 21:35–86, 1975
Levy, H.B. and Sober, H.A.: A simple chromatographic method for preparation of gamma globulin.Proc. Soc. Exp. Biol. Med. 103:250–252, 1960
Mage, R., Lieberman, R., Potter, M., and Terry, W.D.: Immunoglobulin allotypes.In M. Sela (ed.):The Antigens, Vol. 1, p. 300, Academic Press, New York, 1973
Mandy, W.J. and Rodkey, L.S.: Rabbit IgG heavy chains: evolutionary divergence of genes coding for constant region.Immunochemistry 11:29–34, 1974
Mandy, W.J. and Todd, C.W.: Characterization of allotype A11 in rabbits: a specificity detected by agglutination.Immunochemistry 6:811–823, 1969
Mandy, W.J. and Todd, C.W.: Rabbit immunoglobuline allotype A12: a new agglutinating specificity.Biochem. Genet. 4:59–71, 1970
Oudin, J.: Réaction de précipitation spécifique entre des sérums d'animaux de mÊme espèce.C. R. Acad. Sci. 242:2489–2490, 1956a
Oudin, J.: L'Allotypie de certains antigènes protéidiques du sérum.C. R. Acad. Sci. 242:2606–2608, 1956b
Oudin, J.: Allotypy of rabbit serum proteins. I. Immunochemical analysis leading to the individualization of seven main allotypes.J. Exp. Med. 112:107–124, 1960a
Oudin, J.: Allotypy of rabbit serum proteins. II. Relationship between various allotypes: their common antigenic specificity, their distribution in a sample population; genetic implications.J. Exp. Med. 112:125–142, 1960b
Oudin, J.: L'Allotypie des protéines du sérum espèces animales autre que l'homme:In P. Bordet (ed.):Immunologie, pp. 805–855, Flammarion, Paris, 1972
Prahl, J., Mandy, W.J., and Todd, C.W.: The molecular determinants of the A11 and A12 allotypic specificities in rabbit immunoglobulin.Biochemistry 8:4935–4940, 1969
Teherani, J. and Mandy, W.J.: Constant region IgG allotypes in cottontail rabbits: groupe allelic polymorphism.Immunochemistry 13:221–227, 1976a
Teherani, J. and Mandy, W.J.: Constant region IgG allotypes in hares: groupe allelic polymorphism.Immunochemistry 13:401–406, 1976b
Tosi, R. and Landucci-Tosi, S.: Studies of rabbit allotypes by crosslinked antisera.In: R.A. Reisfeld and W.T. Mandy (eds.):Contemporary Topics in Molecular Immunology, Vol. 2, p. 79, Plenum Press, New York, 1973
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cazenave, PA., Brézin, C., Puget, A. et al. Lagomorph-constant region IgG allotypes: Shared e determinants inOchotona sp . Immunogenetics 4, 489–498 (1977). https://doi.org/10.1007/BF01575683
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01575683