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The expression ofI-region gene products on lymphocytes

II. Genetic localization and cellular distribution of MLR determinants

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Abstract

MLR reactivity of lymphocytes from a large number of strain combinations, devised to differ for restricted regions of theH-2 complex, was studied. The reactivities of T and B stimulator cells were compared. It was found that genes for MLR determinants controlling T-and B-cell antigens are distributed along practically the wholeH-2 complex. In all regions, with the exception of theI-C subregion, B cells were found to be stronger stimulators than T cells. The strongest MLR-stimulating antigens were controlled by genes clustering in theI-A andI-B subregions. Consistent correlation was found between Ia incompatibility and MLR reactivity in allI-region-different combinations, suggesting that the Ia antigens may be identical to the MLR-stimulating antigens.

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Abbreviations

MLR:

mixed lymphocyte reaction

CML:

cell-mediated lympholysis

GVHR:

graft-versus-host reaction

Thy-1.1:

synonym forθ AKR

Thy-1.2:

synonym forθ C3H

Ia:

cell-surface antigens controlled by theI region of theH-2 complex

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Author notes

  1. Peter Lonai

    Present address: Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

Authors and Affiliations

  1. Division of Immunology, Department of Medicine, Stanford University School of Medicine, 94305, Stanford, California

    Peter Lonai & Hugh O. McDevitt

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  1. Peter Lonai
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  2. Hugh O. McDevitt
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Additional information

For the definition and nomenclature of theH-2 complex and Ia antigens, see Kleinet al. 1974a and Shreffleret al. 1974.

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Lonai, P., McDevitt, H.O. The expression ofI-region gene products on lymphocytes. Immunogenetics 4, 33–55 (1977). https://doi.org/10.1007/BF01575644

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  • DOI: https://doi.org/10.1007/BF01575644

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