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Multigenic regulation of the primary immune response to ovalbumin in mice

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Abstract

At least four genes regulate the primary immune response to ovalbumin in mice. The ability to be sensitized to transfer delayed type hypersensitivity to ovalbumin is controlled by two genes. One gene,OVA-β, is linked to theH-2 complex and maps to the left ofI-E. The linkage of the other gene,OVA-Bg1, has not been determined, but it segregates independently of theLy M locus, of the heavy chain allotype genes and of certain genes controlling coat color. At least two genes regulate the ability to respond with a primary antiovalbumin antibody response. One gene,OVA-α, is linked to theH-2 complex and maps to the right ofI-E. Discordance of the minimum dose of antigen needed to elicit delayed type hypersensitivity response and antibody suggests that non-H-2 gene(s) regulating the primary antibody response are different fromOVA-Bg1.

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Abbreviations

BSA:

bovine serum albumin

DTH:

delayed type hypersensitivity

H-2 :

major histocompatibility complex of mouse

Ir :

gene — immune response gene

OVA:

ovalbumin

SRBC:

sheep red blood cells

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Author notes

  1. Martha Turner Lubet

    Present address: Immunology Branch, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland

Authors and Affiliations

  1. Department of Microbiology, The University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, 75235, Dallas, Texas

    Martha Turner Lubet & John R. Kettman

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  1. Martha Turner Lubet
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  2. John R. Kettman
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Lubet, M.T., Kettman, J.R. Multigenic regulation of the primary immune response to ovalbumin in mice. Immunogenetics 9, 45–55 (1979). https://doi.org/10.1007/BF01570392

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