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Influence of ampicillin, clindamycin or metronidazole upon the 7α-dehydroxylation of bile acids in the human intestine

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Abstract

The effect of ampicillin, clindamycin and metronidazole upon the 7α-dehydroxylation of cholic acid by the microflora in the intestine was tested in healthy subjects. Clindamycin gave a significant decrease in the 7α-dehydroxylation. With the other two antibiotics, no significant changes were seen.

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Authors and Affiliations

  1. Department of Medical Microbial Ecology, Karolinska Institute, Doktorsringen 4A, 104 01, Stockholm, Sweden

    Karin Andréasson, K. Elisabeth Norin &  Tore Midtvedt

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  1. Karin Andréasson
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  2. K. Elisabeth Norin
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  3. Tore Midtvedt
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Andréasson, K., Norin, K.E. & Midtvedt, T. Influence of ampicillin, clindamycin or metronidazole upon the 7α-dehydroxylation of bile acids in the human intestine. Current Microbiology 16, 329–331 (1988). https://doi.org/10.1007/BF01568540

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