Summary and Conclusions
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1.
The effects of histamine biochemotherapy on 11 non-hospitalized schizophrenics are presented in a preliminary report, and the findings and endocrine interrelationships are analyzed from a physiodynamic viewpoint involving endocrine interrelationships.
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2.
In this study, histamine has been observed to reduce both tolerance and craving.
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3.
ACH, ACTH and cortisone have been reportedto increase tolerance and reduce craving.
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4.
The need for sharp differentiation between cerebral tolerance and craving, as influenced by therapy, is stressed.
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5.
The full significance of this difference in action must await detailed reports on the psychiatric classification of patients under treatment by all groups of investigators.
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6.
The importance of diagnosis is stressed as fundamental to proper endocrine therapy.
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7.
The metabolic approach appears to be a promising avenue for the study of problem drinking just as it is for psychiatric disorders in general.
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Sackler, R.R., Sackler, M.D., Tui, C. et al. On tolerance to and craving for alcohol in histamine-treated schizophrenics. Psych Quar 26, 597–607 (1952). https://doi.org/10.1007/BF01568494
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DOI: https://doi.org/10.1007/BF01568494