Phen/Fen for Weight Loss-1984

Abstract

It has been shown that there are important differences between fenfluramine hydrochloride and the traditional stimulant drugs used in treating obesity. The stimulant anorexiants are believed to act via central catecholamine mechanisms whereas fenfluramine appears to act via serotonergic mechanisms. The traditional stimulant drugs have adverse effects including insomnia, nervousness, increased motor activity, and occasional cardiovascular disturbances including increased pulse rate and increased blood pressure. They also appear to delay the onset of eating and to shorten its duration. Fenfluramine often causes sedative effects and occasionally diarrhea.

Weintraub, M., Hasday, J., Mushlin, A., & Lockwood, D. (1984). A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination. Archives of Internal Medicine, 144(6), 1143–1148. doi: 10.1001/archinte.144.6.1143

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/604539