Abstract
Germ-free mice, tested more than two weeks after removing their cecum, were at least 104 times more resistant than controls to intestinal colonization byClostridium botulinum type A or B. Histologic examinations were done with the cecum and colon taken fromC. botulinum-monoassociated mice. Specimens from mice with severe botulism had normal appearance. In specimens from chronically monoassociated mice, the pathogen was in the lumen, but not attached to the intestine. Scanning electron microscopy suggested a possible association of the pathogen with the mucous gel lining.
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Burr, D.H., Beery, J.T. & Sugiyama, H. Importance of cecum inClostridium botulinum colonization of mice and relationship of organism to large bowel. Current Microbiology 12, 277–281 (1985). https://doi.org/10.1007/BF01567978
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DOI: https://doi.org/10.1007/BF01567978