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Influence of the abdominal vagi and gastric antrum on humoral control of gastric acid secretion

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Abstract

The influence of the abdominal vagi (especially the gastric antral branch), the antrum, and the duodenum on humoral control of gastric acid secretion was studied in 9 dogs with Heidenhain pouches (HP). The dogs were divided into 2 groups and subjected to the following sequential operations:

Group I: (6 dogs) The first operation was section of the antral branch of the vagus nerve. The second operation was antrectomy with Billroth I gastroduodenostomy. The third operation was transthoracic truncal vagotomy.

Group II: (3 dogs) The first operation was antrectomy and Billroth II gastrojejunostomy and the second operation was transthoracic truncal vagotomy. During the control period when the dogs had only an HP, pouch acid secretion and serum gastrin level increased after feeding. After antral vagotomy, both pouch secretion and the serum gastrin level after feeding were significantly lower. The second operation of antrectomy with Billroth I gastroduodenostomy in Group I resulted in a further significant decrease in both pouch acid secretion and serum gastrin level. Similar decreases occurred after the first operation of antrectomy with Billroth II gastrojejunostomy in Group II. In both groups, after the final operation of transthoracic truncal vagotomy, pouch acid secretion tended to increase, while the serum gastrin level increased slightly in Group I but not in Group II. It is concluded that vagal innervation of the antrum plays a role in gastrin release and gastric acid secretion.

Résumé

Nous avons étudié, chez 9 chiens porteurs d'une poche de Heidenhain (PH), l'influence des branches abdominales des nerfs vagues (plus spécialement le rameau antral), de l'antre et du duodénum sur le contrôle hormonal de la sécrétion gastrique acide. Deux groupes de chiens ont été soumis aux opérations suivantes:

Dans le groupe I (6 chiens), la première opération est une section du rameau antral du vague, la deuxième une antrectomie avec gastroduodénostomie de type Billroth I, la troisième une vagotomie par voie thoracique.

Dans le groupe II (3 chiens), la première opération est une antrectomie avec gastrojéjunostomie de type Billroth II et la seconde une vagotomie par voie thoracique.

Pendant la période de contrôle, la sécrétion acide de la PH et le taux de gastrine sérique augmentent après un repas. Après vagotomie antrale, la sécrétion de la PH et les valeurs de gastrine sérique sont réduites de façon significative. Dans le groupe I, l'antrectomie avec gastroduodénostomie diminue encore la sécrétion d'acide de la PH et la gastrinémie. Dans le groupe II, F antrectomie avec gastrojéjunostomie donne des réductions de même importance. Dans les deux groupes, la sécrétion acide de la PH tend à s'élever après vagotomie par voie thoracique. La gastrinémie augmente légèrement dans le groupe I, mais pas dans le groupe II. En conclusion, l'innervation vagale de l'antre influence la libération de gastrine et la sécrétion gastrique acide.

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Authors and Affiliations

  1. The First Department of Surgery, School of Medicine, Tokushima University, Kuramoto-cho, Tokushima, Japan

    Hideo Watanabe M.D., Mahito Kinoshita M.D., Toshihiko Kondo M.D., Masatoshi Konishi M.D., Hideyuki Miyamoto M.D., Yoshiaki Kano M.D., Toshiaki Kushida M.D. & Nobuhiko Komi M.D.

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  1. Hideo Watanabe M.D.
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  2. Mahito Kinoshita M.D.
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  3. Toshihiko Kondo M.D.
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  4. Masatoshi Konishi M.D.
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  5. Hideyuki Miyamoto M.D.
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  6. Yoshiaki Kano M.D.
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  7. Toshiaki Kushida M.D.
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  8. Nobuhiko Komi M.D.
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Watanabe, H., Kinoshita, M., Kondo, T. et al. Influence of the abdominal vagi and gastric antrum on humoral control of gastric acid secretion. World J. Surg. 2, 359–363 (1978). https://doi.org/10.1007/BF01561520

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