Abstract
Of 1100 women whose primary and/or metastatic breast cancers have been analyzed for estrophilin, 30% are receptor-rich and 70% receptor-poor. On the basis of 134 treated patients, nearly two-thirds of the receptor-rich group can expect objective benefit from endocrine therapy, whereas few if any of the receptor-poor patients will respond. Thus, estrophilin assay indicates the proper type of therapy for 85 to 90% of women with advanced breast cancer. Analysis of the primary tumor in the mastectomy specimen offers promise in predicting hormone dependency in metastases that appear up to 5 years later.
Résumé
Chez 1100 femmes, la tumeur mammaire primitive et/ou des métastases ont été testées pour la présence de récepteurs d'oestrogènes: 30% sont riches en récepteurs, 70% sont pauvres. D'après l'expérience de 134 malades traitées, on peut s'attendre à une réponse objectivement favorable à l'hormonothérapie dans prè des 2/3 du groupe riche en récepteurs. Pour le groupe pauvre en récepteurs, il n'y a que peu ou pas réponse. La détermination des récepteurs d'oestrogène indique donc le traitement adéquat dans 85–90% des cancers du sein au stade avancé. L'analyse de la tumeur enlevée par mastectomie permet de prédire l'hormonodépendance des métastases qui apparaÎtraient jusqu'à 5 années plus tard.
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This investigation was supported by USPHS Contract N01 CB-43969 and Grant 5 P01 CA-24599.
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Jensen, E.V., Block, G.E., Ferguson, D.J. et al. Estrogen receptors in breast cancer. World J. Surg. 1, 341–342 (1977). https://doi.org/10.1007/BF01556853
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DOI: https://doi.org/10.1007/BF01556853