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Lactic acidosis, diabetes mellitus and the biguanide compounds

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Riassunto

Dopo un breve schema dei fattori che regolano i livelli di lattato nel plasma dei soggetti normali e diabetici, gli AA. riassumono la storia, il possibile meccanismo di azione e le applicazioni terapeutiche dei derivati della guanidina. Viene discussa la possibilità che questi farmaci possano incrementare il pericolo dell'acidosi lattica.

Resume

Après un bref schème des facteurs qui réglent les niveaux du lactate dans le plasma des sujets normaux et diabétiques, les AA. résument l'histoire, le possible mécanisme d'action et les applications thérapeutiques des dérivés de la guanidine. On discute sur la possibilité que ces médicaments puissent accroître la période de l'acidose lactique.

Resumen

Al cabo de breve esquema de los factores que regulan los niveles de lactato en el plasma de sujetos normales y diabéticos, los AA. resumen la historia, el modo de acción posible y las aplicaciones terapéuticas de los derivados de la guanidina. Se discute la posibilidad que estos fármacos puedan aumentar el período de la acidosis láctica.

Zusammenfassung

Nach einer kurzen Schematisierung der Faktoren, welche die Laktatspiegel im Plasma normaler Personen und Diabetiker regeln, fassen die AA. die Geschichte, den moeglichen Wirkungsmechanismus und die therapeutischen Anwendungen der Guanidin-Derivate zusammen. Es wird die Moeglichkeit der Steigerung der Azidose-Periode (Milchsaeure) durch diese Arzneimittel diskutiert.

Summary

After a brief outline of the factors regulating plasma lactate levels in normal and diabetic subjects, the AA. summarize the history, the possible mechanism of action and the therapeutic applications of the guanidine derivatives. The possibility that these drugs may increase the danger of lactic acidosis is discussed.

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Bibliografia

  1. Alpert N. R.: Lactate Production and Removal and the Regulation of Metabolism - Ann. N.Y. Acad. Sci.119 995, 1965.

    Article  CAS  PubMed  Google Scholar 

  2. Alterman S. L., Lopez-Gomez A. A.: Phenformin Effect on Body Weight, Lipids and Glucose Regulation - Ann. N.Y. Acad. Sci.148 884, 1968.

    Article  CAS  PubMed  Google Scholar 

  3. Altschuld R. A., Kruger F. A.: Inhibition of Hepatic Gluconeogenesis in Guinea Pig by Phenformin - Ann. N.Y. Acad. Sci.148 613, 1968.

    Article  Google Scholar 

  4. Azérad E.: Le traitement du diabète de l'adulte par le N-N-diméthylbiguanide - Un. méd. Can.92 1251, 1963.

    Google Scholar 

  5. Barta L.: Milchsäure-Acidose bei diabetischem Koma - Wschr. Kinderheilk.116 608, 1968.

    CAS  Google Scholar 

  6. Beaser S. B.: Oral Treatment of Diabetes Mellitus - J. Amer. med. Ass.187 887, 1964.

    Article  CAS  Google Scholar 

  7. Beckmann R.: Zum Wirkungsmechanismus der Biguanide - Dtsch. med. Wschr.90 1589, 1965.

    Article  CAS  PubMed  Google Scholar 

  8. Beckmann R.: The Fate of Biguanides in Man - Ann. N.Y. Acad. Sci.148 820, 1968.

    Article  CAS  PubMed  Google Scholar 

  9. Bergen S. S. Jr.,Norton W. S.: Clinical and Metabolic Effects of Phenethylbiguanide -Diabetes9 183, 1960.

    Article  PubMed  Google Scholar 

  10. Berger S., Downey J. L., Traisman H. S.: Effect of Phenformin on the Cortisone Glucose Tolerance Test - Ann. N.Y. Acad. Sci.148 859, 1968.

    Article  CAS  PubMed  Google Scholar 

  11. Bernier G. M., Miller M., Springate C. S.: Lactic Acidosis and Phenformin Hydrochloride- J. Amer. med. Ass.184 43, 1963.

    Article  CAS  Google Scholar 

  12. Bessman S. P.: A Molecular Basis for the Mechanism of Insulin Action - Amer. J. Med.40 740, 1966.

    Article  CAS  PubMed  Google Scholar 

  13. Bodo R., Marks H. P.: Relation of Synthalin to Carbohydrate Metabolism- J. Physiol. (Lond.)65 83, 1928.

    Article  CAS  Google Scholar 

  14. Boshell B. R., Roddam R. F., McAdams G. L.: Effects of Phenformin on Insulin Reserve and Release - Ann. N.Y. Acad. Sci.148 756, 1968.

    Article  CAS  PubMed  Google Scholar 

  15. Brugi A., Gironi G., Ferrari M. L.: Trattamento del diabete mellito con dimetilbiguanide. Esperienza di 280 casi - Clin. ter.42 247, 1967.

    CAS  PubMed  Google Scholar 

  16. Burns D., Sharpe J. S.: The Parathyroids: Tetania Parathyreopriva: Its Nature, Cause and Relations to Idiopathic Tetany. Part V. Guanidin and Methyl-Guanidin in the Blood and Urine in Tetania Parathyreopriva and in the Urine in Idiopathic Tetany - Quart. J. exp. Physiol.10 345, 1916.

    Article  Google Scholar 

  17. Butterfield W. J. H.: The Effects of Phenformin on Peripheral Glucose Utilization and Insulin Action in Obesity and Diabetes Mellitus - Ann. N.Y. Acad. Sci.148 724, 1968.

    Article  CAS  PubMed  Google Scholar 

  18. Cain S. M., Dunn J. E. II: Transient Arterial Lactic Acid Changes in Unanesthetized Dogs at 21,000 Feet - Amer. J. Physiol.206 1437, 1964.

    CAS  PubMed  Google Scholar 

  19. Cannon W. B.: Acidosis in Shock, Hemorrhage and Gas Infection - J. Amer. med. Ass.70 531, 1918.

    Google Scholar 

  20. Clarke B. F., Duncan L. J. P.: Comparison of Chlorpropamide and Metformin Treatment on Weight and Blood-Glucose Response of Uncontrolled Obese Diabetics - Lancet1 123, 1968.

    Article  CAS  PubMed  Google Scholar 

  21. Clarke D. W., Forbath N.: The Effects of Phenformin on the Isolated Rat Diaphragm -Diabetes9 167, 1960.

    Article  CAS  PubMed  Google Scholar 

  22. Cohen Y., Costerousse O.: Étude autoradiographique chez la souris d'un antidiabétique oral, le N-N-diméthylbiguanide marqué au carbone 14 - Thérapie16 109, 1961.

    CAS  Google Scholar 

  23. Craig J. W., Miller M., Woodward H. Jr.,Merik E.: Influence of Phenethylbiguanide on Lactic, Pyruvic and Citric Acids in Diabetic Patients - Diabetes9 186, 1960.

    Article  CAS  PubMed  Google Scholar 

  24. Creutzfeldt W., Söling H.-D., Zardáy Z.: The Combined Use of Insulin, Tolbutamide and Biguanides in the Treatment of Diabetes Mellitus. Clinical Significance and Experimental Findings - Metabolism12 264, 1963.

    CAS  PubMed  Google Scholar 

  25. Cucurachi L., Strata A., Zuliani U., Cucurachi P., Dell'Anna A.: Le biguanidi nel trattamento dell'obesità. Nota 1. Ricerca clinica controllata con placebo, anoressanti, fenformina e metformina - Acta diabet. lat.5 580, 1968.

    Article  CAS  Google Scholar 

  26. Czyżyk A., Ławecki J., Sadowski J., Ponikowska I., Szczepanik Z.: Effect of Biguanides on Intestinal Absorption of Glucose - Diabetes17 492, 1968.

    Article  PubMed  Google Scholar 

  27. Dale H. H., Graham G., Lawrence R. D., Cammidge P. J.: Discussion on Action of Synthalin - Proc. roy. Soc. Med.21 21, 1928.

    Google Scholar 

  28. Dalidowicz J. E., McDonald H. J.: Site of the in Vitro Inhibition of Cholesterol Biosynthesis by Tolbutamide and Phenethylbiguanide - Biochemistry4 1138, 1965.

    Article  CAS  PubMed  Google Scholar 

  29. Danowski T. S.: Lactic Acidosis in Diabetes Mellitus - J. Amer. med. Ass.184 47, 1963.

    Article  Google Scholar 

  30. Danowski T. S.: The Lactic-Acidosis Syndromes - Diabetes12 277, 1963.

    Article  CAS  PubMed  Google Scholar 

  31. Danowski T. S., Nabarro J. D. N.: Hyperosmolar and Other Types of Nonketotic Coma in Diabetes - Diabetes14 162, 1965.

    Article  CAS  PubMed  Google Scholar 

  32. Davidoff F. F.: Oral Hypoglycemic Agents and the Mechanism of Diabetes Mellitus - New Engl. J. Med.278 148, 1968.

    Article  CAS  PubMed  Google Scholar 

  33. Davidson M. B., Bozarth W. R., Challoner D. R., Goodner C. J.: Phenformin, Hypoglycemia and Lactic Acidosis - New Engl. J. Med.275 886, 1966.

    Article  CAS  PubMed  Google Scholar 

  34. Debry G., Anziani M., Cherrier P., Laurent J.: Étude de la lactacidémie á jeun chez les diabétiques traités par le N-N-diméthylbiguanide - Diabète (Le Raincy)12 239, 1964.

    CAS  Google Scholar 

  35. Debry G., Cherrier F.-P.: Étude du mode d'excrétion du N-N-diméthylbiguanide chez le diabétique adulte - Thérapie20 351, 1965.

    CAS  PubMed  Google Scholar 

  36. Debry G., Cherrier P., Laurent J.: Étude des perturbations du métabolisme de l'acide lactique au cours du diabète sucré - Path. et Biol.14 13, 1966.

    CAS  Google Scholar 

  37. Debry G., Laurent J., Cherrier P., Viniaker H.: L'influence des biguanides sur le métabolisme de l'acide lactique chez le diabétique. In: Rein et Foie - Maladies de la Nutrition9 161, 1966.

    CAS  Google Scholar 

  38. Dempsey M. E.: Inhibition of Lipid Biosynthesis - Ann. N.Y. Acad. Sci.148 631, 1968.

    Article  CAS  PubMed  Google Scholar 

  39. Doar J. W. H., Wynn V., Cramp D. G.: Blood Pyruvate and Plasma Glucose Levels during Oral and Intravenous Glucose Tolerance Tests in Obese and Non-Obese Women - Metabolism17 690, 1968.

    Article  CAS  PubMed  Google Scholar 

  40. Dossetor J. B., Zborowski D., Dixon H. B., Pare J. A. P.: Hyperlactatemia Due to Hyperventilation: Use of CO2 Inhalation - Ann. N.Y. Acad. Sci.119 1153, 1965.

    Article  Google Scholar 

  41. Dragstedt L. E.: Physiology of Parathyroid Glands - Physiol. Rev.7 499, 1927.

    Google Scholar 

  42. Duncan G. G., Duncan T. G., Schatanoff J.: Refractory Obesity and Diabetes - Ann. N.Y. Acad. Sci.148 906, 1968.

    Article  CAS  PubMed  Google Scholar 

  43. Duncan L. J. P., Baird J. D.: Compounds Administered Orally in Treatment of Diabetes Mellitus - Pharmacol. Rev.12 91, 1960.

    CAS  PubMed  Google Scholar 

  44. Ewy G. A., Pabico R. C., Mahler J. F., Mintz D. H.: Lactate Acidosis Associated with Phenformin Therapy and Localized Tissue Hypoxia. Report of a Case Treated by Hemodialysis- Ann. intern. Med.59 878, 1963.

    Article  CAS  PubMed  Google Scholar 

  45. Fajans S. S., Moorhouse J. A., Doorenbos H., Louis L. H., Conn J. W.: Metabolic Effects of Phenethylbiguanide in Normal Subjects and in Diabetic Patients - Diabetes9 194, 1960.

    Article  CAS  PubMed  Google Scholar 

  46. Falcone A. B., Mao R. L., Shrago E.: A Study of the Action of Hypoglycemia-Producing Biguanide and Sulfonylurea Compounds on Oxidative Phosphorylation - J. biol. Chem.237 904, 1962.

    CAS  PubMed  Google Scholar 

  47. Faludi G., Bendersky G., Gerber P.: Functional Hypoglycemia in Early Latent Diabetes -Ann. N.Y. Acad. Sci.148 868, 1968.

    Article  CAS  PubMed  Google Scholar 

  48. Frank E., Nothmann M., Wagner A.: Über synthetisch dargestellte Körper mit insulinartiger Wirkung auf den normalen und diabetischen Organismus - Klin. Wschr.5 2100, 1926.

    Article  CAS  Google Scholar 

  49. Frank E., Nothmann M., Wagner A.: Die Synthalinbehandlung des Diabetes mellitus. I-III -Dtsch. med. Wschr.52 2067, 1926.

    Article  Google Scholar 

  50. Frank E., Nothmann M., Wagner A.: Die Synthalinbehandlung des Diabetes mellitus. IV. Indikationen und Kontraindikationen - Dtsch. med. Wschr.52 2107, 1926.

    Article  Google Scholar 

  51. Frank E., Stern R., Nothmann M.: Die Guanidin- und Dimethylguanidin-Toxikose des Säugetiers und ihre physio-pathologische Bedeutung - Z. ges. exp. Med.24 341, 1921.

    Article  CAS  Google Scholar 

  52. Frank E., Wagner A.: Der gegenwärtige Stand der Synthalinbehandlung des Diabetes mellitus- Ergebn. ges. Med.13 451, 1929.

    Google Scholar 

  53. Gergens E., Baumann E.: Ueber das Verhalten des Guanidin, Dicyandiamidin und Cyanamid im Organismus - Pflüger's Arch. ges. Physiol.12 205, 1876.

    Article  Google Scholar 

  54. Gershberg H., Javier Z., Hulse M., Hecht A.: Influence of Hypoglycemic Agents on Blood Lipids and Body Weight in Ketoacidosis-Resistant Diabetics - Ann. N.Y. Acad. Sci.148 914, 1968.

    Article  CAS  PubMed  Google Scholar 

  55. Gley E.: Traité de Physiologie - Baillère, Paris, 1928.

    Google Scholar 

  56. Gottlieb A., Duberstein J., Geller A.: Phenformin Acidosis - New Engl. J. Med.267 806, 1962.

    Article  CAS  PubMed  Google Scholar 

  57. Grodsky G. M., Karam J. M., Pavlatos F. Ch.,Forsham P. H.: Reduction by Phenformin of Excessive Insulin Levels after Glucose Loading in Obese and Diabetic Subjects - Metabolism12 278, 1963.

    CAS  PubMed  Google Scholar 

  58. Guillory R. J., Slater E. C.: The Action of Substituted Guanidines on Mitochondrial Respiration and on the ADP-ATP Exchange Reaction - Biochim. biophys. Acta (Amst.)105 221, 1965.

    Article  CAS  Google Scholar 

  59. Halmos P. B., Nelson J. K., Lowry R. C.: Hyperosmolar Non-Ketotic Coma in Diabetes -Lancet1 675, 1966.

    Article  CAS  PubMed  Google Scholar 

  60. Hill A. V., Lupton H.: Muscular Exercise, Lactic Acid and the Supply and Utilization of Oxygen - Quart. J. Med.16 135, 1923.

    Article  CAS  Google Scholar 

  61. Hollobaugh S. L., Rao M. B., Kruger F. A.: Evidence for Significant «Non-Peripheral» Effects of Phenformin (DBI) on Glucose Metabolism in Man - Clin. Res.15 428, 1968.

    Google Scholar 

  62. Hollunger G.: Guanidines and Oxidative Phosphorylations - Acta pharmacol. (Kbh.)11 (suppl. 1), 1, 1955.

    CAS  Google Scholar 

  63. Huckabee W. E.: Abnormal Resting Blood Lactate. I. The Significance of Hyperlactatemia in Hospitalized Patients - Amer. J. Med.30 833, 1961.

    Article  Google Scholar 

  64. Huckabee W. E.: Abnormal Resting Blood Lactate. II. Lactic Acidosis - Amer. J. Med.30 840, 1961.

    Article  CAS  PubMed  Google Scholar 

  65. Jangaard N. O., Pereira J. N., Pinson R.: Metabolic Effects of the Biguanides and Possible Mechanism of Action - Diabetes17 96, 1968.

    Article  CAS  PubMed  Google Scholar 

  66. Johnson H. K., Waterhouse C.: Relationship of Alcohol and Hyperlactatemia in Diabetic Subjects Treated with Phenformin - Amer. J. Med.45 98, 1968.

    Article  CAS  PubMed  Google Scholar 

  67. Jurgesen J. C.: Dialysis for Lactic Acidosis - New Engl. J. Med.278 1350, 1968.

    CAS  PubMed  Google Scholar 

  68. Kauffmann-Cosla O., Vasilco O.: Experimentelle Untersuchungen in vivo über die Wirkung des Synthalins auf die Oxidation der Zelle - Arch. exp. Path. Pharmak.159 154, 1931.

    Article  Google Scholar 

  69. Koch W. F.: On the Occurrence of Methylguanidine in the Urine of Parathyroidectomized Animals - J. biol. Chem.12 313, 1912.

    CAS  Google Scholar 

  70. Kreisberg R. A.: Glucose Metabolism in Normal and Obese Subjects: Effect of Phenformin -Diabetes17 481, 1968.

    Article  CAS  PubMed  Google Scholar 

  71. Kreisberg R. A.: Kinetics of Glucose Utilization in Obesity: the Effect of Phenformin -Ann. N.Y. Acad. Sci.148 743, 1968.

    Article  CAS  PubMed  Google Scholar 

  72. Kruger F. A., Skillman T. G., Hamwi G. J., Grubbs R. C., Danforth N.: The Mechanism of Action of Hypoglycemic Guanidine Derivatives - Diabetes9 170, 1960.

    Article  CAS  PubMed  Google Scholar 

  73. Lacher J., Lasagna L.: Phenformin and Lactic Acidosis - Clin. Pharmacol. Ther.7 477, 1966.

    Article  CAS  PubMed  Google Scholar 

  74. Lavieuville M.: Différences entre les divers biguanides antidiabétiques - Journées Ann. Diabétol. Hôtel-Dieu, Paris, 1964.

    Google Scholar 

  75. Leaf A., McCully K. S.: Acidosis and Shock in a Patient with Diabetes, Cirrhosis and Renal Failure - New Engl. J. Med.278 1004, 1968.

    Article  Google Scholar 

  76. Madison L. L., Unger R. H.: Effect of Phenformin on Peripheral Glucose Utilization in Human Diabetic and Nondiabetic Subjects - Diabetes9 202, 1960.

    Article  CAS  PubMed  Google Scholar 

  77. Maggi G., Fratino P., Rodari T.: Sul meccanismo d'azione della fenetilbiguanide (PEBG). XI. Effetti sulla glicolisi e sulla glicogenosintesi nell'animale normale - Boll. Soc. ital. Biol. sper.44 155, 1968.

    CAS  PubMed  Google Scholar 

  78. Markees S.: Cocarboxylase in Diabetic Acidosis; Experimental and Clinical Findings -B Vitamine, Klin. Physiol. Chem. Probl., Symp., Berlin 1966, pag. 171.

    Google Scholar 

  79. Mårtinsson J.: Effects of Guanidine and Synthalin on the Citric Acid Metabolism - Acta med. scand.125 82, 1946.

    Article  Google Scholar 

  80. McDonald H. J., De Chatelet L. R.: The Effects of Three Oral Hypoglycemic Agents on the Incorporation of Leucine-C14 into Protein by Liver Microsomes of Normal and Alloxan-Diabetic Rats - Life Sci.6 183, 1967.

    Article  CAS  PubMed  Google Scholar 

  81. Meinert C. L., Schwartz T. B.: The Relationship of Treatment to Weight in a Randomized Study of Maturity-Onset Diabetes - Ann. N.Y. Acad. Sci.148 875, 1968.

    Article  CAS  PubMed  Google Scholar 

  82. Meyer M. F.: Étude sur le mode d'action des biguanides hypoglycémiants - C. R. Acad. Sci. (Paris)251 1928, 1960.

    Google Scholar 

  83. Meyerhof O.: Die Energieumwandlungen im Muskel. I. Ueber die Beziehungen der Milchsäure zur Wärmebildung und Arbeitsleistung des Muskels in der Anaerobiose - Pflüger's Arch. ges. Physiol.182 232, 1920.

    Article  CAS  Google Scholar 

  84. Minot A. S.: The Mechanism of the Hypoglycemia Produced by Guanidine and Carbon Tetrachloride Poisoning and Its Relief by Calcium Medication - J. Pharmacol. exp. Ther.43 295, 1931.

    CAS  Google Scholar 

  85. Mirsky S.: Influences of Hypoglycemic Therapy on Blood Lipids and Body Weight in Diabetes Mellitus - Ann. N.Y. Acad. Sci.148 937, 1968.

    Article  CAS  PubMed  Google Scholar 

  86. Muntoni S., Boero A., Corona M., Floris M.: La dimetilbiguanide nella terapia del diabete -Clin. ter.35 227, 1965.

    CAS  PubMed  Google Scholar 

  87. Paton D. N., Findlay L.: The Parathyroids: Tetania Parathyreopriva: Its Nature, Cause and Relation to Idiopathic Tetany. Part IV. The Etiology of the Condition and Its Relationship to Guanidin and Methylguanidin Intoxication - Quart. J. exp. Physiol.10 315, 1916.

    Article  Google Scholar 

  88. Pedersen J., Olesen E. S.: Observations on the Mechanism of Increased Weight Loss during Metformin Administration in Obesity - Acta endocr. (Kbh.)57 683, 1968.

    CAS  Google Scholar 

  89. Pereira J. N., Jangaard N. O., Pinson E. R.: Some Metabolic Effects of Phenformin in Rat Adipose Tissue - Diabetes16 869, 1967.

    Article  CAS  Google Scholar 

  90. Pereira V. G., Wajchenberg B. L., Shnaider J.: Mechanism of Action of Phenethylbiguanide in Normal Subjects - Diabetes16 302, 1967.

    Article  CAS  PubMed  Google Scholar 

  91. Peretz D. I., Scott H. M., Duff J., Dossetor J. B., MacLean L. D., McGregor M.: The Significance of Lactic Acidemia in the Shock Syndrome - Ann. N.Y. Acad. Sci.119 1133, 1965.

    Article  CAS  PubMed  Google Scholar 

  92. Petrides P.: Über den derzeitigen Stand der Diabetes-Behandlung - Klin. Mbl. Augenheilk.146 777, 1965.

    Google Scholar 

  93. Petrides P., Schräpler P.: Experimentelle Untersuchungen zum Wirkungsmechanismus von Buformin - Klin. Wschr.44 1209, 1966.

    Article  CAS  PubMed  Google Scholar 

  94. Pomeranze J., Fujiy H., Mouratof G. T.: Clinical Report of a New Hypoglycemic Agent -Proc. Soc. exp. Biol. (N.Y.)95 193, 1957.

    Article  CAS  Google Scholar 

  95. Proctor D. W., Stowers J. M.: Fatal Lactic Acidosis after an Overdose of Phenformin -Brit. med. J.4 216, 1967.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Ramachander G., Finkelman F., Li H., Glassman J. M.: Lactic Acid Tolerance in Phenformin-Treated Animals - Ann. N.Y. Acad. Sci.148 653, 1968.

    Article  CAS  PubMed  Google Scholar 

  97. Roginsky M. S., Sandler J.: Phenformin in Human Obesity - Ann. N.Y. Acad. Sci.148 892, 1968.

    Article  CAS  PubMed  Google Scholar 

  98. Sament S., Schwartz M.: Severe Diabetic Stupor without Ketosis -S. Afr. med. J.31 893, 1957.

    CAS  PubMed  Google Scholar 

  99. Schaefer L. E.: Hyperlipidemia - Ann. N.Y. Acad. Sci.148 925, 1968.

    Article  CAS  PubMed  Google Scholar 

  100. Schäfer F.: Site-Specific Uncoupling and Inhibition of Energy Transfer by Biguanides -Biochim. biophys. Acta (Amst.)93 279, 1964.

    Article  Google Scholar 

  101. Selvini A.: Gli ipoglicemizzanti orali - Ann. medici9 991, 1965.

    Google Scholar 

  102. Selvini A., Brugi A., Emanueli A.: Sull'impiego dell'ER 102 nel trattamento del diabete mellito - Minerva med.58 189, 1967.

    CAS  PubMed  Google Scholar 

  103. Sgambato S., Frascolla N., Rufino G., Torella R.: La dimetilbiguanide nella terapia del diabete mellito: osservazioni clinico-metaboliche - Biochim. appl. (Parma)14 151, 1967.

    CAS  Google Scholar 

  104. Shaw R. A., Kryston L. J., Mills L. C.: Plasma Fucose and Fucose Tolerance in Diabetes Mellitus - Ann. N.Y. Acad. Sci.148 787, 1968.

    Article  CAS  PubMed  Google Scholar 

  105. Siesjö B. K., Kjällquist A., Zwetnow N.: The CSF Lactate-Pyruvate Ratio in Cerebral Hypoxia - Life Sci.7 45, 1968.

    Article  PubMed  Google Scholar 

  106. Söling H.-D., Moshagen D., Skutella E., Kneer P., Creutzfeldt W.: Die Wirkung von N1,n-butylbiguanid auf den Stoffwechsel der isolierten perfundierten Leber normaler und alloxandiabetischer ketotischer Ratten - Diabetologia3 318, 1967.

    Article  PubMed  Google Scholar 

  107. Spadolini I.: Sur les lésions expérimentales des nerfs mésentériques et de l'appareil parathyroïdien par rapport aux intoxications d'origine intestinale - Arch. ital. Biol.77 17, 1926.

    Google Scholar 

  108. Spadolini I.: L'apparato paratiroideo in rapporto ai meccanismi di difesa naturale dei tessuti epiteliali. Contributo allo studio della patogenesi della sindrome paratireopriva - Arch. Fisiol.25 566, 1927.

    Google Scholar 

  109. Spadolini I.: L'ipocalcemia da tossine batteriche nella insufficienza paratiroidea relativa -Boll. Soc. ital. Biol. sper.3 768, 1928.

    CAS  Google Scholar 

  110. Spadolini I., Castelli G.: Le alterazioni della mucosa intestinale come cause di precoci batteriemie negli animali operati di estirpazione delle ghiandole paratiroidi - Arch. Fisiol.25 159, 1927.

    Google Scholar 

  111. Sproule B. J., Phillipson E. A., Couves C. M., Brownlee R. T.: Acute Pulmonary Hypertension in Idiopathic Lactic Acidosis - Canad. med. Ass. J.94 141, 1966.

    CAS  PubMed  PubMed Central  Google Scholar 

  112. Staub H., Jezler A.: Zum Synthalinmechanismus - Z. klin. Med.112 1, 1929.

    Google Scholar 

  113. Staub H., Kung O.: Zum Synthalinmechanismus - Klin. Wschr.7 1365, 1928.

    Article  CAS  Google Scholar 

  114. Steiner D. F., Williams R. H.: Respiratory Inhibition and Hypoglycemia by Biguanides and Decamethylene Diguanidine - Biochim. biophys. Acta (Amst.)30 325, 1958.

    Article  Google Scholar 

  115. Sterne J.: Du nouveau dans les antidiabétiques, le N-N-diméthyldiguanide - Maroc méd.106 1295, 1957.

    Google Scholar 

  116. Sterne J.: The Present State of Knowledge on the Mode of Action of the Antidiabetic Diguanides - Metabolism13 791, 1964.

    Article  CAS  PubMed  Google Scholar 

  117. Sterne J.: Mécanisme d'action des biguanides antidiabétiques - Presse méd.72 17, 1964.

    CAS  PubMed  Google Scholar 

  118. Strohmeyer G., Dölle W., Sauer H.: Milchsäure-Acidose mit Exzesslactat bei Diabetes Mellitus - Dtsch. med. Wschr.90 2238, 1965.

    Article  CAS  PubMed  Google Scholar 

  119. Tranquada R. E., Bernstein S., Martin H. E.: Irreversible Lactic Acidosis Associated with Phenformin Therapy - J. Amer. med. Ass.184 37, 1963.

    Article  CAS  Google Scholar 

  120. Tranquada R. E., Grant W. J., Peterson C. R.: Lactic Acidosis - Arch. intern. Med.117 192, 1966.

    Article  CAS  PubMed  Google Scholar 

  121. Tyberghein J. M., Williams R. H.: Metabolic Effects of Phenethylbiguanide, a New Hypoglycemic Compound - Proc. Soc. exp. Biol. (N.Y.)96 29, 1957.

    Article  CAS  Google Scholar 

  122. Tzagournis J. F., Seidensticker J. F., Hamwi G. J.: Metabolic Abnormalities in Premature Coronary Disease: Effects of Therapy - Ann. N.Y. Acad. Sci.148 945, 1968.

    Article  CAS  PubMed  Google Scholar 

  123. Underhill F. P., Blatherwick N. R.: Studies in Carbohydrate Metabolism. VI. The Influence of Thyreoparathyroidectomy upon the Sugar Content of the Blood and the Glycogen Content of the Liver - J. biol. Chem.18 87, 1914.

    CAS  Google Scholar 

  124. Ungar G., Freedman L., Shapiro S. L.: Pharmacological Studies of a New Oral Hypoglycemic Agent - Proc. Soc. exp. Biol. (N.Y.)95 190, 1957.

    Article  CAS  Google Scholar 

  125. Ungar G., Psychoyos S., Hall H. A.: Action of Phenethylbiguanide, a Hypoglycemic Agent, on Tricarboxylic Acid Cycle - Metabolism9 36, 1960.

    CAS  PubMed  Google Scholar 

  126. Unger R. H., Madison L. L., Carter N. W.: Tolbutamide-Phenformin in Ketoacidosis-Resistant Patients - J. Amer. med. Ass.174 2132, 1960.

    Article  CAS  Google Scholar 

  127. Volk B. W., Lazarus S. S.: Histologic and Histochemical Observations in the Rabbit after Phenethylbiguanide - Diabetes9 174, 1960.

    Article  CAS  Google Scholar 

  128. Walker R. S., Linton A. L., Thomson W. S. T.: Mode of Action and Side Effects of Phenformin Hydrochloride - Brit. med. J.2 1567, 1960.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  129. Watanabe C. K.: Studies in the Metabolic Changes Induced by Administration of Guanidine Bases. 1. Influence of Injected Guanidine Hydrochloride upon Blood Sugar Content - J. biol. Chem.33 253, 1918.

    CAS  Google Scholar 

  130. Waxler S. H., Leef M. R.: Phenformin-Induced Weight Loss in Obese Mice - Ann. N.Y. Acad. Sci.148 647, 1968.

    Article  CAS  PubMed  Google Scholar 

  131. Wegmann R., Lageron A., Guha S., Petkov P.: Histoenzymology of the Guinea Pig Endocrine Pancreas and the Effect of Biguanidine - Ann. Histochim.12 137, 1967.

    CAS  PubMed  Google Scholar 

  132. Weinberg E. D.: Antimicrobial Activities of Biguanides - Ann. N.Y. Acad. Sci.148 587, 1968.

    Article  CAS  PubMed  Google Scholar 

  133. Westervelt F. B. Jr.,Owen J. A. Jr.,Hornbaker J. H. Jr.,Gorsuch T. L.: Lactic Acidosis. A Case Treated with THAM and Hemodialysis - Virginia med. Mth.93 251, 1966.

    Google Scholar 

  134. Wick A. N., Larson E. R., Serif G. S.: A Site of Action of Phenethylbiguanide - A Hypoglycemic Compound - J. biol. Chem.233 296, 1958.

    CAS  PubMed  Google Scholar 

  135. Wick A. N., Stewart C. J., Serif G. S.: Tissue Distribution of C14-Labeled β-Phenethylbiguanide- Diabetes9 163, 1960.

    Article  CAS  PubMed  Google Scholar 

  136. Wilansky D. L., Shochat G.: The Course of Latent Diabetes - Ann. N.Y. Acad. Sci.148 848, 1968.

    Article  CAS  PubMed  Google Scholar 

  137. Williams R. H.: Textbook of Endocrinology - Saunders, Philadelphia, 1968, pag. 751.

    Google Scholar 

  138. Williams R. H., Tyberghein J. M., Hyde P. M., Nielsen R. L.: Studies Related to the Hypoglycemic Action of Phenethyldiguanide - Metabolism6 311, 1957.

    CAS  PubMed  Google Scholar 

  139. Williamson J. R., Walker R. S., Renold A. E.: Metabolic Effects of Phenethylbiguanide (DBI) on the Isolated Perfused Rat Heart - Metabolism12 1141, 1963.

    CAS  PubMed  Google Scholar 

  140. Wishart G. M.: The Parathyroids: Tetania Parathyreopriva: Its Nature, Cause, and Relations to Idiopathic Tetany. Part VI: The Action of the Blood Serum of Animals in Tetania Parathyreopriva on the Skeletal Muscles of the Frog - Quart. J. exp. Physiol.10 354, 1916.

    Google Scholar 

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Authors and Affiliations

  1. National Institutes of Health Diabetes Training Program N°, AM05474, USA

    Janette D. Bigelow-Sherman (trainee)

  2. Division of Research, Sinai Hospital of Detroit, Department of Physiology and Pharmacology, Wayne State University Medical School, Detroit, Michigan, USA

    Piero P. Foà

Authors
  1. Janette D. Bigelow-Sherman
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  2. Piero P. Foà
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Bigelow-Sherman, J.D., Foà, P.P. Lactic acidosis, diabetes mellitus and the biguanide compounds. Acta diabet. lat 6, 507–522 (1969). https://doi.org/10.1007/BF01548068

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