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Heterogeneity of T-cell neoplasias as defined by monoclonal antibodies

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Summary

Surface marker studies were carried out on neoplastic cell samples (peripheral aspirates and skin biopsies) of 302 patients with non-Hodgkin lymphomas (221 patients) and acute lymphatic leukaemias (81 patients). In 11 patients with non-Hodgkin lymphomas (5%) and eight patients with acute lymphatic leukaemia (10%), the neoplastic cells possessed phenotypic characteristics of T cells. The investigations were carried out by means of an indirect immunofluorescence technique using a panel of monoclonal antibodies (OKT 3, 4, 6, 8, 9, 10; OKM 1; HNK 1 and VIL A 1). In addition, conventional markers (SIg, E-R 4°, E-R 37°, absorbed polyclonal rabbit antithymus and anti-TDT) were used. Our results, which show a pronounced phenotypic surface marker heterogeneity between the group of T-cell neoplasias, emphasize the diagnostic value of monoclonal antisera as compared to polyclonal reagents. Eleven different surface marker profiles were observed in the 19 patients investigated.

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik, Abt. für Hämatologie und Onkologie, Klinikum Steglitz, Freie Universität Berlin, Germany

    F. Herrmann, B. Komischke, G. Sieber & H. Rühl

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  1. F. Herrmann
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  2. B. Komischke
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  3. G. Sieber
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  4. H. Rühl
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Supported in part by grants from the Tumorzentrum Berlin e. V.

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Herrmann, F., Komischke, B., Sieber, G. et al. Heterogeneity of T-cell neoplasias as defined by monoclonal antibodies. Klin Wochenschr 61, 807–812 (1983). https://doi.org/10.1007/BF01496725

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  • DOI: https://doi.org/10.1007/BF01496725

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