Summary
In a group of subjects who had undergone unilateral nephrectomy 6 to 84 months previously, plasma renin activity was lower than in control subjects having both kidneys. After admission of the patients to hospital and they being kept on a standard diet of mild sodium restriction, PRA rose slightly in both groups without affecting the difference initially present. Injection of 60 mg furosemide induced a steep and marked increase in PRA in the control subjects, whereas the response of the unilaterally nephrectomized subjects was delayed and suppressed. In most of the latter subjects, PRA did not exceed values measured in control subjects before furosemide injection. It is concluded that the suppressed activity and responsiveness of the renin-angiotensin system after unilateral nephrectomy is part of the adjustment of the renal function to the reduction in renal mass.
Zusammenfassung
Bei zehn Patienten, bei denen 6 bis 84 Monate vor der Untersuchung aus verschiedenen Gründen eine unilaterale Nephrektomie vorgenommen worden war, fand sich eine im Vergleich zu zehn normalen Personen erniedrigte Plasmareninaktivität (PRA). Unter konstanten Bedingungen und Standarddiät mit leicht vermindertem Salzgehalt nahm in beiden Gruppen die PRA leicht zu, jedoch blieb die Differenz bestehen. Intravenöse Injektion von 60 mg Furosemid hatte bei den Kontrollpersonen einen starken Anstieg der PRA zur Folge, während bei den unilateral nephrektomierten Patienten die Reaktion verzögert und abgeschwächt war. Bei den meisten dieser Patienten erreichte die PRA nur die bei normalen Personen vor Furosemidinjektion gemessenen Werte. Es wird geschlossen, daß die verminderte Aktivität und Ansprechbarkeit des Renin-Angiotensin-Systems nach unilateraler Nephrektomie die Folge der Anpassung der Nierenfunktion an die Verminderung der Nierenmasse ist.
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Deilmann, W., Gross, F., Lamprecht, F. et al. Suppressed Renin Response in Unilaterally Nephrectomized Subjects. Klin Wochenschr 50, 112–115 (1972). https://doi.org/10.1007/BF01484818
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DOI: https://doi.org/10.1007/BF01484818