Skip to main content

Advertisement

SpringerLink
Log in

Chromosomenanomalien bei malignen Tumoren

Chromosomal abnormalities in human neoplasia

  • Übersichten
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

Multiple connections exist between chromosomal aberrations and malignant tumors. It is the aim of the present article to summarize the data known so far in view of i) cancer-prone chromosome abnormalities, ii) chromosome abnormalities related to tumors and iii) chromosome abnormalities related to carcinogens. In some instances it seemed useful to discuss the findings in man in connection with the results of in vitro experimental data.

Zusammenfassung

Chromosomenanomalien sind auf vielfältige Weise mit malignen Erkrankungen verknüpft. Die vorliegende Übersicht gliedert die bisher bekannten Daten beim Menschen unter den Gesichtspunkten: Chromosomenanomalien a) als Ursache von Tumoren, b) als Indikator von Tumoren, c) als Indikator für Cancerogene. Die noch unvollständigen Daten beim Menschen werden, wo das sinnvoll erscheint, durch Befunde der experimentellen Onkologie ergänzt und interpretiert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Adamson, J.W., Fialkow, P.J., Murphy, S., Prchal, J.F., Steinmann, L.: Polycythemia vera: Stem-cell and probable clonal origin of the disease. New Engl. J. Med.295, 913–916 (1976)

    PubMed  Google Scholar 

  2. Ames, B.N., Durton, E., Yamasaki, Lee, F.D.: Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc. Nat. Acad. Sci. USA70, 2281 (1973)

    PubMed  Google Scholar 

  3. Atkin, N.B.: Chromosomes in human malignant tumors: a review and assessment. In chromosomes and cancer. J. German (ed) New York: John Wiley and sons, 375–422 (1974)

    Google Scholar 

  4. Auerbach, A.D., Wolman, S.R.: Susceptibility of Fanconis's anemia fibroblasts to chromosome damage by carcinogens. Nature261, 494–496 (1976)

    PubMed  Google Scholar 

  5. Awa, A.A.: Cytogenetic and oncogenic effects of the ionizing radiations of the atomic bombs. In chromosomes and Cancer, J. German (ed) New York: John Wiley and sons, 637–674 (1974)

    Google Scholar 

  6. Bartram, C.R., Koske-Westphal, Th., Passarge, E.: Chromatid exchanges in ataxia telangiectasia, Bloom syndrome, Werner syndrome, and xeroderma pigmentosum. Ann. Human Genet. London40, 79–86 (1976)

    Google Scholar 

  7. Bloom, A.D., Mc Neill, J.A., Nakamura, F.T.: Epstein-Barr virus infection of lymphoid cells and the cytogenetics of established human lymphocyte cell lines. In chromosomes and cancer J. German (ed) New York: Wiley and sons, 565–599 (1974)

    Google Scholar 

  8. Boveri, T.: Zur Frage der Entstehung maligner Tumoren. Jena: G. Fischer (1914)

    Google Scholar 

  9. Brookes, P., Lawley, P.D.: Evidence for the binding of polynuclear aromatic hydrocarbons to the nucleic acids of mouse skin: relation between carcinogenic power of hydrocarbons and their binding to deoxyribonucleic acid. Nature202, 781 (1964)

    PubMed  Google Scholar 

  10. Brown, M.W.C., Buckton, K.E., Langlands, H.O., Woodcock, G.E.: The identification of lymphocyte clones with chromosome structural aberrations in irradiated man and women. Int. J. Radial. Biol.13, 155–168 (1967)

    Google Scholar 

  11. Cantu, J.M., del Castillo, V., Jiminez, M., Ruiz-Barquin, M. Chromosomal instability in incontinentia pigmenti. Ann. Genet. (Paris)16, 117–119 (1973)

    PubMed  Google Scholar 

  12. Cleaver, J.E.: Defective repair replication of DNA in xeroderma pigmentosum. Nature218, 652–656 (1968)

    PubMed  Google Scholar 

  13. Cleaver, J.E., Bootsma, D., Friedberg, E.: Human diseases with genetically altered DNA repair processes. Genetics79, 215–225 (1975)

    PubMed  Google Scholar 

  14. Codish, S.D., Paul, B.: Reversible appearance of a specific chromosome which suppresses malignancy. Nature252, 610–612 (1974)

    PubMed  Google Scholar 

  15. Cohen, M.D., Ariel, I., Dagan, J.: Chromosome deletion (46, xy, 20q-) in sideroblastic anemia. Isr. J. Med. Sci.10, 1393–1396 (1974)

    PubMed  Google Scholar 

  16. Comings, D.E.: A general theory of carcinogenesis. Proc. Nat. Acad. Sci. US70, 3324–3328 (1973)

    Google Scholar 

  17. Croce, C.M., Koprowski, H.: Somatic cell hybrids between mouse peritoneal macrophages and SV 40-transformed human cells. I. Positive control of the transformed phenotype by the human chromosome 7 carryning the SV 40 genome. J. Exp. Med.140, 1221–1229 (1973)

    Google Scholar 

  18. de Grouchy, J., Turleau, Catharine: Clonal evolution in the myeloid leukemias. In chromosomes and cancer, J. German (ed) New York: John Wiley and sons, 287–311 (1974)

    Google Scholar 

  19. Emerit, I., Levy, A., Housset, E.: Chromosomal breakage in scleroderma. Possible presence of a breakage factor in the serum of patients. Ann. Genet. (Paris)16, 135–138 (1973)

    PubMed  Google Scholar 

  20. Emerit, I., Housset, E., de Grouchy, J., Camus, J.P.: Chromosomal breakage in diffuse scleroderma. Eur. J. Clin. Biol. Res.16, 684–694 (1971)

    Google Scholar 

  21. Evans, H.J., Brown, C., Mc Lean, A.S. (eds): Human radiation cytogenetics. Amsterdam: North Holland Publishing Co. (1967)

    Google Scholar 

  22. Fleischmann, T., Harkansson, C.H., Levan, A., Möller, T.: Multiple chromosome aberrations in a lymphosarcomatous tumor. Hereditas70, 243–258 (1972)

    PubMed  Google Scholar 

  23. German, J.: Genes which increase chromosomal instability in somatic cells and predispose to cancer. Progr. Med. Genet.8, 61–101 (1972)

    Google Scholar 

  24. German, J.: Bloom's syndrome II. In chromosomes and cancer J. German (ed) New York: Wiley and sons, 601–617 (1974)

    Google Scholar 

  25. Gorlin, R.J., Goltz, R.W.: Multiple nevoid basal-cell epithelioma, jaw cysts, and bifid rib: A syndrome. New Engl. J. Med.262, 908–912 (1960)

    PubMed  Google Scholar 

  26. Goth-Goldstein, R.: Repair of DNA damaged by alkylating carcinogens is defective in xeroderma pigmentosum-derived fibroblasts. Nature267, 81–82 (1977)

    PubMed  Google Scholar 

  27. Harnden, D.G., Taylor, A.M.R., Oxford, J.M.: Chromosomal instability in cells cultured from patients susceptible to cancer. Genetis74, 109 (1973)

    Google Scholar 

  28. Harnden, D.G.: Viruses, chromosomes, and tumors: the interaction between viruses and chromosomes. In chromosomes and cancer, J. German (ed) New York: John Wiley and sons, 151–190 (1974a)

    Google Scholar 

  29. Harnden, D.G.: Ataxia telangiectasia syndrome: cytogenetic and cancer aspects. In chromosomes and cancer, J. German (ed) New York: John Wiley and sons, 619–636 (1974b)

    Google Scholar 

  30. Harnden, D.G.: Cytogenetics of human neoplasia. Genetics of human cancer (J.J. Mulvihill, R.W. Miller, J.F. Fraumeni, Jr. eds. New York: Raven Press 87–104 (1977)

    Google Scholar 

  31. Harris, H., Miller, O.J., Klein, Y., Worst, P., Tachibana, T.: Suppression of malignancy by cell fusion. Nature223, 363–368 (1969)

    PubMed  Google Scholar 

  32. Harris, H.: Cell fusion and the analysis of malignancy. Proc. R. Soc. Lond. D.179, 1–20 (1971)

    Google Scholar 

  33. Hayashi, K., Schmid, W.: The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi's anemia and to Trenimon-induced aberrations in human lymphocytes and fibroblasts. Humangenetik29, 201–206 (1975)

    PubMed  Google Scholar 

  34. Hecht, F., Kaiser Mc Caw, Barbara: Chromosome instability syndromes. Genetics of human cancer (J.J. Mulvihill, R.W. Miller, J.F. Fraumeni, Jr. eds.) New York: Raven Press 105–123 (1977)

    Google Scholar 

  35. Herrmann, J.: Delayed mutation as a cause of retinoblastoma: application to genetic counseling. In cancer and genetic, D. Bergsma (ed) Birth defects: Vol XII1, 79–90 (1976)

    Google Scholar 

  36. Hirschhorn, K.: Chromosomes and cancer. In cancer and genetic, D. Bergsma (ed) Birth defects: Vol XII1, 113–121 (1976)

    Google Scholar 

  37. Hoar, D.I., Sargent, P.: Chemical mutagen hypersensitivity in ataxia telangiectasia. Nature261, 590–592 (1976)

    PubMed  Google Scholar 

  38. Horland, A.A., Wolman, S.R., Cox, R.P.: Cytogenetic studies in patients with the basal cell nevus syndrome and their relatives. Amer. J. Hum. Genet.27, 477 (1975)

    Google Scholar 

  39. Jarvis, J.E., Ball, G., Rickinson, A.B., Epstein, M.A.: Cytogenetic studies on human lymphoblastoid cell lines from Burkitt's lymphomas and other sources. Int. J. Cancer14, 716–721 (1974)

    PubMed  Google Scholar 

  40. Jonasson, J., Galerton, J., Lindstern, J., Simonsson-Lindemalm, C., Zech, L.: Trisomy 8 in acute myeloblastic leukemia and sideroachrestic anemia. Blood43, 557 (1974)

    PubMed  Google Scholar 

  41. Kakati, S., Oshimura, M., Sandberg, A.A.: Chromosomes and causation of human cancer and leukemia 19. common markers in various tumors. Cancer38, 770–777 (1976)

    PubMed  Google Scholar 

  42. Kitchin, F.D., Ellsworth, R.M.: Pleiotropic effects of the gene for retinoblastome. J. Med. Genet.11, 244–246 (1974)

    PubMed  Google Scholar 

  43. Knudson, A.G., Maedows, Anna T., Nichols, W.W., Hill, Rosina: Chromosomal deletion and retinoblastoma. New Engl. J. Med.295, 1120–1123 (1976)

    PubMed  Google Scholar 

  44. Kraemer, K.H., Coon, H.G., Petinga, R.A., Barrett, S.F., Rahe, A.E., Robbins, J.H.: Genetic heterogeneity in xeroderma pigmentosum: complementation groups and their relationship to DNA repair rates. Proc. Nat. Acad. Sci. USA72, 59–63 (1975)

    PubMed  Google Scholar 

  45. Latt, S.A.: Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes. Proc. Nat. Acad. Sci. USA70, 3395–3399 (1973)

    PubMed  Google Scholar 

  46. Lawler, S.D., Millard, R.E., Kay, H.E.M.: Further cytogenetical investigation in polydythemia vera. Eur. J. Cancer6, 223–233 (1970)

    PubMed  Google Scholar 

  47. Manolov, G., Manolova, Y.: Marker band in one chromosome 14 from Burkitt lymphomas. Nature237, 33–34 (1972)

    PubMed  Google Scholar 

  48. Mark, J.: The human meningioma: a benign tumor with specific chromosoma characteristics. In chromosomes and cancer, J. German (ed) New York: John Wiley and sons, 497–517 (1974)

    Google Scholar 

  49. Mc Culloch, P.B., Deut, P.B., Hayes. Paula R, Liao, S.K.: common and individually specific chromosomal characteristics of cultured human melanoma. Cancer Research36, 398–404 (1976)

    PubMed  Google Scholar 

  50. Mc Dougall, J.K.: Adeno virus-induced chromosome aberrations in human cells. J. Gen. Virol.12, 43–51 (1971)

    PubMed  Google Scholar 

  51. Miller, O.L.: Cell hybridization in the study of the malignant process, including cytogenetic aspects. In chromosomes and cancer, J. German (ed) New York: John Wiley and sons, 522–563 (1974)

    Google Scholar 

  52. Mitelman, F., Mark, J., Levan, G.: Chromosomes of six primary sarcomas induced in the chinese hamster by 7,12-dimethylbenz (α) anth-racene Hereditas72, 311–318 (1972a)

    PubMed  Google Scholar 

  53. Mitelman, F., Levan, G.: The chromosomes of primary 7,12-dimethylbenz (α) anthracene-induced rat sarcomas. Hereditas71, 325–334 (1972b)

    PubMed  Google Scholar 

  54. Mitelman, F., Mark, J., Levan, G., Levan, A.: Tumor etiology and chromosome pattern. Science176, 1340 (1972c)

    PubMed  Google Scholar 

  55. Mitelman, F., Levan, G., Brandt, L.: Highly malignant cells with normal karyotype in G-banding. Hereditas80, 291–293 (1975)

    PubMed  Google Scholar 

  56. Mitelman, F., Levan, G., Nilsson, P.G., Brandt, L.: Non-random karyotypic evolution in chronic myeloid leukemia. Int. J. Cancer18, 24–30 (1970a)

    Google Scholar 

  57. Mitelman, F., Nilsson, P.G., Levan, G., Brandt, L.: Non-random chromosome changes in acute myeloid leukemia. Chromosome banding examination of 30 cases at diagnosis. Int. J. Cancer18, 31–38 (1976b)

    PubMed  Google Scholar 

  58. Mitelman, F., Levan, G.: Do only a few chromosomes carry genes of prime importance for malignant transformation? Lancet 264 (1976c)

  59. Mitelman, F., Levan, G.: Clustering of aberrations to specific chromosomes in human neoplasms II. Hereditas 82, 167–174 (1976d)

    PubMed  Google Scholar 

  60. Morrhead, P.S., Saksela, E.: Non-random chromosome aberrations in SV 40-transformed human cells. I. Cell Comp. Phiol.62, 57–83 (1963)

    Google Scholar 

  61. Müller, H., Stadler, G.R.: Chromosomes and human neoplasms. Eur. J. Pediat123, 1–13 (1976)

    Google Scholar 

  62. Muldal, S., Lajtha, L.G.: Chromosomes and leukemia. In chromosomes and cancer, J. German (ed) New York: John Wiley and sons, 451–480 (1974)

    Google Scholar 

  63. Ohno, S.: Aneuploidy as a possible maens employed recessive phenotypes. In chromosomes and cancer, J. German (ed) New York: John Wiley and sons, 77–94 (1974)

    Google Scholar 

  64. Orye, E., Delbeke, M.J., Vandenbeele, B.: Retinoblastoma and long arm deletion of chromosome 13. Attempts to define the deleted segment. Clin. Genet.5, 457–464 (1974)

    PubMed  Google Scholar 

  65. Oshimura, M., Hayata, I., Kakati, S., Sandberg, A.A.: Chromosomes and causation of human cancer and leukemia 17. Bauding studies in acute myeloblastic leukemia (AML). Cancer38, 748–761 (1971)

    Google Scholar 

  66. Oshimura, M., Sandberg, A.A.: Chromosomal 6q- anomaly in acute lymphoblastic leukemia. The LancetII, 1405–1406 (1976)

    Google Scholar 

  67. Passarge, E.: The human caryotype; analysis of chromosomes in mitosis and evaluation of cytogenetic data. In methods in human cytogenetics Schwarzacher, Wolf, Passarge (ed) Berlin: Springer-Verlag, 135–205 (1974a)

    Google Scholar 

  68. Passarge, E.: Angeborene und hereditäre Fehlbildungs-Syndrome. In Klinik der Gegenwart. München: Urban und Schwarzenberg, 357–422 (174b)

  69. Passarge, E., Bartram, C.R.: Somatic recombination as possible prelude to malignant transformation. In cancer and genetics, D. Bergsma (ed) Birth defects Vol XII,1, 177–180 (1976)

    Google Scholar 

  70. Perry, P., Evans, H.J.: Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange. Proc. Nat. Acad. Sci. USA258, 121–125 (1975)

    Google Scholar 

  71. Rowley, Janet D.: Do human tumors show a chromosome pattern specific for each etiologic agent? J. Nat. Cancer Inst.52, 315–320 (1974)

    PubMed  Google Scholar 

  72. Rowley, Janet D.: Non-random chromosomal abnormalities in hematologic disorders of man. Proc. Nat. Acad. Sci.72, 152–156 (1975a)

    PubMed  Google Scholar 

  73. Rowley, Janet D.: Abnormalities of chromosome 1 in myeloproliferative disorders. Cancer36, 1748–1757 (1975b)

    PubMed  Google Scholar 

  74. Rowley, Janet D.: Are non-random karyotypic changes related to etiologic agents? Genetics of Human Cancer (J.J. Mulvihill, R.W. Miller and J.F. Fraumeni Jr. ed) New York: Raven Press, 125–136 (1977)

    Google Scholar 

  75. Rüdiger, H.W., Kohl, F., Mangels, W., v. Wichert, P., Bartram, C.R., Wöhler, W., Passarge, E.: Benzpyrene induces sister chromatid exchanges in cultured human lymphocytes. Nature262, 290–292 (1976)

    PubMed  Google Scholar 

  76. Rüdiger, H.W.: Genetisch bedingte Risikofaktoren für maligne Tumoren beim Menschen. Dtsch. med. Wschr. in press (1977)

  77. Sakurai, M., Sandberg, A.A.: Chromosomes and causation of human cancer and leukemai. 18. missing y in acute myeloblastic leukemia (AML) and pH 1-positive chronic myelocytic leukemia (CML). Cancer38, 762–769 (1976)

    PubMed  Google Scholar 

  78. Sandberg, A.A., Ishihara, T.C., Crosswhite, L.H., Hanschka, T.S.: Comparison of chromosome constitution in chronic myeloid leukemia and other proliferative disorders. Blood20, 393–423 (1962)

    PubMed  Google Scholar 

  79. Sasaki, M.S., Tonomura, A.: A high susceptibility of Fanconi's anemia to chromosome breakage by DNA crosslinking agents. Cancer Res.33, 1829–1836 (1973)

    PubMed  Google Scholar 

  80. Schroeder, T.M., German, J.: Bloom's syndrome and Fanconi's anemia: demonstration of two distinctive patterns of chromosome disruption and rearrangement. Humangenetik25, 299–306 (1974)

    PubMed  Google Scholar 

  81. Seabright, M.: High resolution studies on the pattern of induced exchanges in the human karyotype. Chromosoma40, 333–346 (1973)

    PubMed  Google Scholar 

  82. Strong, L.C.: Theories of pathogenesis: mutation and cancer. Genetics of Human Cancer (J.J. Mulvihill, R.W. Miller, and J.F. Fraumeni Jr. (ed) New York: Raven Press, 401–415 (1977)

    Google Scholar 

  83. Sugiyama, T., Kurita, Y., Nishizuka, Y.: Chromosome abnormality in rat leukemia induced by 7,12-dimethylbenz (α) anthracene. Science158, 1058–1059 (1967)

    PubMed  Google Scholar 

  84. Taylor, A.M.R., Harnden, D.G., Arlett, C.F., Harcourt, S.A., Lehmann, A.R., Stevens, S., Bridgei, B.A.: Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature258, 427–429 (1975)

    PubMed  Google Scholar 

  85. Tough, I.M., Buckton, K.E., Baike, A.G., Brown, C.: X-ray-induced chromosome damage in man. Lancet2, 849 (1960)

    PubMed  Google Scholar 

  86. Visfeldt, J., Jensen, Grethe, Hippe, E.: On thorotrast leukemia. Acta Path. Microbiol. Scand. Sect. A,83, 373–378 (1975)

    Google Scholar 

  87. Whang-Peng, J., Canellos, G.P., Carbone, P.P.: Clinical implications of cytogenetic variants in chronic myelocytic leukemia CML). Blood32, 755–766 (1968)

    PubMed  Google Scholar 

  88. Whitehouse, H.L.K.: Chromosome integration of viral DNA: the open-replicon hypothesis of carcinogenesis. In chromosomes and cancer, J. German (ed) New York: John Wiley and sons, 41–76 (1974)

    Google Scholar 

  89. Wiener, F., Klein, G., Harris, H.: The analysis of malignancy by cell fusion. IV. Hybrids between tumor cells and malignant L cell derivative. J. Cell Sci.12, 253–261 (1973)

    PubMed  Google Scholar 

  90. Wolf, U.: Theodor Boveri and his book “On the problem of the origin of malignant tumors”. In Chromosomes and cancer J. German (ed) New York: John Wiley and sons, 3–20 (1974)

    Google Scholar 

  91. Yamamoto, T., Rabinowitz, Z., Sachs, L.: Identification of the chromosomes that control malignancy. Nature New Biol. Vol243, 247–250 (1973)

    PubMed  Google Scholar 

  92. Zech, L., Haglund, U., Nilsson, K., Klein, G.: Characteristic chromosomal abnormalities in biopsies and lymphoid cell lines from patients with Burkitt and non-Birkitt lymphomas. Int. J. Cancer17, 47–56 (1975)

    Google Scholar 

  93. zur Hausen, H.: Association of adeno virus type 12 deoxyribonucleic acid with host cell chromosomes. J. Virol.2, 218–223 (1968)

    PubMed  Google Scholar 

  94. zur Hausen, H.: Induction of specific chromosomal aberrations by adeno virus type 12 in human embryonic kidney cells. J. Virol.1, 1174–1185 (1967

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I. Medizinische Universitätsklinik der Universität, Martinistraße 52, D-2000, Hamburg 20, Bundesrepublik Deutschland

    C. R. Bartram &  H. W. Rüdiger

Authors
  1. C. R. Bartram
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. W. Rüdiger
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bartram, C.R., Rüdiger, H.W. Chromosomenanomalien bei malignen Tumoren. Klin Wochenschr 56, 733–741 (1978). https://doi.org/10.1007/BF01476762

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01476762

Key words

Schlüsselwörter

Search

Navigation