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Neue Einblicke in die Entstehung von komplexen Karyotypen bei Krebs

  • Wissenschaft
  • Genomische Instabilität
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Abstract

Cancer cells differ from healthy cells by massively altered genomes. This includes point mutations as well as chromosomal rearrangements and changes in chromosome numbers. Novel in vitro models mimic chromosomal aberrations and allow their systematic analysis. Here we present recent findings how changes in chromosome numbers and their structure alter physiology of human cells and instigate further genomic instability, thus recapitulating the processes that occur during tumorigenesis.

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Authors and Affiliations

  1. Abteilung Molekulare Genetik, TU Kaiserslautern, Paul-Ehrlich-Straße 24, D-67663, Kaiserslautern, Deutschland

    Sara Vanessa Bernhard & Zuzana Storchova

Authors
  1. Sara Vanessa Bernhard
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  2. Zuzana Storchova
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Corresponding author

Correspondence to Zuzana Storchova.

Additional information

Sara Vanessa Bernhard 2013–2016 Bachelor „Biowissenschaften‟ an der TU Kaiserslautern. 2016–2018 Master „Cell- and Neurobiology‟ an der TU Kaiserslautern. Dort seit 2018 Promotion in der Abteilung Molekulare Genetik.

Zuzana Storchova 1995–1999 Promotion an der Karls-Universität Prag, Tschechien. 1999–2001 Post-doc am Institute of Molecular Cancer Research, Universität Zürich, Schweiz. 2001–2007 Postdoc am Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA, USA. 2008–2016 Gruppenleiterin am Max-Planck-Institut für Biochemie, Martinsried. Seit 2016 Professorin für Molekulare Genetik der TU Kaiserslautern.

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Bernhard, S.V., Storchova, Z. Neue Einblicke in die Entstehung von komplexen Karyotypen bei Krebs. Biospektrum 25, 382–384 (2019). https://doi.org/10.1007/s12268-019-1065-3

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  • DOI: https://doi.org/10.1007/s12268-019-1065-3

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