Skip to main content
SpringerLink
Log in

Immunglobulin-Ablagerungen in Lymphadenose-Zellen

Deposits of immunoglobulins in the cells of chronic lymphocytic leukemia

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

Cristalloid inclusions were demonstrated in the perinuclear space and the ergastoplasm of cells of chronic lymphocytic leukemia. These inclusions and the immunoglobulins of the cell membrane consisted of IgG. The leukemic cells were able to synthesize, but not to secrete, monoclonal immunoglobulins.

Zusammenfassung

Im perinucleären Spalt und Ergastoplasma von Lymphadenose-Zellen wurden kristalloide Ablagerungen beobachtet; diese und die membrangebundenen Immunglobuline bestanden aus IgG. Somit besaßen die leukämischen Zellen die Fähigkeit zur Bildung, aber nicht zur Abgabe eines monoklonalen Immunglobulins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Bernard, J., Bessis, M., Soulier, J.P., Thiéry, J.P.: Etude au microscope électronique d'une leucémie lymphoïde avec cristaux intracytoplasmiques. Rev. Hémat.14, 227 (1959)

    Google Scholar 

  2. Böyum, A.: Separation of leucocytes from blood and bone marrow. Scand. J. clin. Lab. Invest.21, Suppl. 97 (1968)

    Google Scholar 

  3. Cawley, J.C., Barker, C.R., Britchford, R.D., Smith, J.L.: Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukaemia. Clin. exp. Immunol.13, 407 (1973)

    PubMed  Google Scholar 

  4. Fateh-Moghadam, A.: Paraproteinämische Hämoblastosen. In: Handbuch innerer Medizin, Hrsg. H. Schwiegk, Bd. 2. Berlin-Heidelberg-New York: Springer 1974

    Google Scholar 

  5. Franklin, E.C.: Some properties of the breakdown products of human 7 S γ-globulin and antibodies. J. clin. Invest.39, 986 (1960)

    Google Scholar 

  6. Gonatas, N.K., Antoine, J.-C., Stieber, A., Avrameas, S.: Surface immunoglobulins of thymus and lymph node cells demonstrated by the peroxidase coupling technique. Lab. Invest.26, 253 (1972)

    PubMed  Google Scholar 

  7. Huber, H., Michlmayr, G., Asamer, H., Huber, Ch., Braunsteiner, H.: Die Differenzierung menschlicher Blutlymphocyten mit immunologischen und autoradiographischen Methoden. Klin. Wschr.50, 504 (1972)

    PubMed  Google Scholar 

  8. Huhn, D.: Feinstruktur peripherer Lymphocyten bei chronischer lymphatischer Leukämie. Dtsch. med. Wschr.95, 897 (1970)

    PubMed  Google Scholar 

  9. Huhn, D., Asamer, H.: Neuartige Einschlüsse im Ergastoplasma peripherer Lymphozyten bei Virusinfekt. Acta haemat. (Basel)50, 245 (1973)

    PubMed  Google Scholar 

  10. Hurez, D., Flandrin, G., Preud'homme, J.L., Seligmann, M.: Unreleased intracellular monoclonal macroglobulin in chronic lymphocytic leukaemia. Clin. exp. Immunol.10, 223 (1972)

    PubMed  Google Scholar 

  11. Jondal, M., Holm, G., Wigzell, H.: Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J. exp. Med.136, 207 (1972)

    PubMed  Google Scholar 

  12. Laszlo, J., Gerber, H.J., Sommer, J.R.: Composition and structure of cytoplasmic globules in leukemic lymphocytes. Blood29, 77 (1967)

    PubMed  Google Scholar 

  13. Moroz, C., Shalmon, L., Hahn, J.: Synthesis of surface immunoglobulin by lymphocyte leukemia cells in vitro. Europ. J. Immunol.3, 16 (1973)

    Google Scholar 

  14. Schmalzl, F., Huhn, D., Asamer, H., Rindler, R., Braunsteiner, H.: Cytochemistry and ultrastructure of pathologic granulation in myelogenous leukemia. Blut27, 243 (1973)

    PubMed  Google Scholar 

  15. Schrek, R.: Ultrastructure of blood lymphocytes from chronic lymphocytic and lymphosarcoma cell leukemia. J. nat. Cancer Inst.48, 51 (1972)

    PubMed  Google Scholar 

  16. Seligmann, M.: B-cell and T-cell markers in lymphoid proliferations. New Engl. J. Med.290, 1483 (1974)

    PubMed  Google Scholar 

  17. Stein, H., Kaiserling, E., Lennert, K., Parwaresch, M.R.: Makroglobulinbildende chronische lymphatische Leukämie ohne Makroglobulinämie. Klin. Wschr.51, 389 (1973)

    PubMed  Google Scholar 

  18. Thiel, E., Dörmer, P., Rodt, H., Thierfelder, S.: Quantitative Immunautoradiographie einzelner Zellen. Mikrophotometrische Quantifizierung antigener Bindungsstellen auf Lymphocyten und leukämischen Zellen. Z. Immun.-Forsch.147, 338 (1974)

    Google Scholar 

  19. Thiel, E., Dörmer, P., Eulitz, M.: Quantitative125I-Autoradiographie einzelner Zellen. Histochemie, in press 1974

  20. Wilson, J.D., Hurdle, A.D.F.: Surface immunoglobulins on lymphocytes in chronic lymphocytic leukaemia and lymphosarcoma. Brit. J. Haemat.24, 563 (1973

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lehrstuhl für Innere Medizin, spez. Hämatologie an der I. Medizinischen Klinik der Universität München, Germany

    D. Huhn, E. Thiel & H. Rodt

  2. Institut für Hämatologie der GSF, München

    D. Huhn, E. Thiel & H. Rodt

Authors
  1. D. Huhn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Thiel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Rodt
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Studie im Rahmen Assoziation Hämatologie Euratom-GSF Nr. 031-64-1 BIAD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Huhn, D., Thiel, E. & Rodt, H. Immunglobulin-Ablagerungen in Lymphadenose-Zellen. Klin Wochenschr 53, 317–320 (1975). https://doi.org/10.1007/BF01469058

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01469058

Key words

Schlüsselwörter

Search

Navigation