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Disaccharidasen der Dünndarmschleimhaut der Ratte unter einer cytostatischen Behandlung mit 5-Fluorouracil

Intestinal disaccharidases in rats treated with 5-fluoro-uracil

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Summary

Activities of rat intestinal disaccharidases are decreased following treatment even with low doses of 5-fluorouracil. Higher doses of the cytostatic drug cause morphological alterations of intestinal mucosa accompanied by a marked drop in enzyme activities. After a single dose of 5-fluoro-uracil, reduced disaccharidase activities are maintained for a couple of days even after morphological restitution of the mucosa.

Malabsorption of disaccharides associates with cytostatic treatment should be paid more attention also in man.

Zusammenfassung

5-Fluorouracil führt schon in relativ niedriger Dosierung zu einer Verminderung der Disaccharidase-Aktivitäten in der Dünndarmschleimhaut der Ratte. Bei höheren Dosierungen kommt es neben morphologischen Veränderungen der Darmmucosa zu einem erheblichen Abfall der Disaccharidase-Aktivitäten, die nach einer Einzeldosis auch nach morphologischer Restitution noch über Tage vermindert sein können. Der therapeutisch induzierten Disaccharid-Malabsorption sollte auch bei der zytostatischen Behandlung des Menschen größere Aufmerksamkeit geschenkt werden.

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  1. Medizinische Klinik, Pathologisches Institut und Institut für Medizinische Statistik und Dokumentation der Universität Erlangen-Nürnberg, Germany

    G. Hartwich, W. Domschke, F. Matzkies, H. -J. Pesch & H. Prestele

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Hartwich, G., Domschke, W., Matzkies, F. et al. Disaccharidasen der Dünndarmschleimhaut der Ratte unter einer cytostatischen Behandlung mit 5-Fluorouracil. Klin Wochenschr 52, 930–938 (1974). https://doi.org/10.1007/BF01468940

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