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Correction of Damaging Effects of Cisplatin-Containing Polychemotherapy on the Intestinal Epithelium with Tussilago farfara L. Polysaccharides

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Bulletin of Experimental Biology and Medicine Aims and scope

A possibility for correction of damaging effects of polychemotherapy on the intestinal epithelium with Tussilago farfara L. polysaccharides was studied on C57Bl/6 mice with Lewis lung carcinoma. The polysaccharides had protective and/or stimulating effects on the intestinal epithelium during polychemotherapy and promoted reparative regeneration in the intestine.

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References

  1. Abramov ME, Mashchelueva AYu. Cisplatin-ebeve. The relevance of the questions on the application. Effekt. Farmakoter. 2011;(22):42-45. Russian.

  2. Gadzhieva ZM, Zhminchenko VM, Baigarin EK. . Effect of carrageenan on morphometric parameters of the intestinal mucosa. Vopr. Pitaniya. 2015;84(S5):29. Russian.

    Google Scholar 

  3. Zufarov KA, Baibekov IM, Khodzhimetov AA. Compensatory and Adaptive Processes in the Intestine. Moscow, 1974. Russian.

    Google Scholar 

  4. Korolyeva IA, Velsher LZ, Kazyulin AN, Kucheryavy YuA, Oganesyan TS. Changes in gastric and duodenal mucosa during adjuvant and neoadjuvant treatments with taxanes and doxorubicin in patients with breast cancer. Sib. Onkol. Zh. 2010;(2):5-10. Russian.

    Google Scholar 

  5. Kuznetsova TA, Besednova NN, Somova LM, Makarenkova ID, Plekhova NG, Drobot EI, Kovalev NN, Usov VV. Experimental evaluation of the effectiveness of wound dressings based on biologically active substances from marine hydrobionts. Russ. J. Marine Biol. 2016;42(5):427-432.

    Article  CAS  Google Scholar 

  6. Manual on Experimental (Preclinical) Study of New Pharmacological Substances, Khabriev RU, ed. Moscow, 2005. Russian.

  7. Safonova EA, Razina TG, Zueva EP, Lopatina KA, Efimova LA, Gur’ev AM, Rybalkina OYu, Khotimchenko YuS. Prospects for the Use of Plant Polysaccharides in Complex Treatment of Malignant Tumors. Eksp. Klin. Farmakol. 2012;75(9):42-47. Russian.

    CAS  PubMed  Google Scholar 

  8. Pastwa E, Poplawski T, Lewandowska U, Somiari S.B, Blasiak J, Somiari R.I. Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells. Int. J. Biochem. Cell Biol. 2014;53:423-431.

    Article  CAS  Google Scholar 

  9. Wang B, Han Y, Zang J. Comparing irinotecan/cisplatin with etoposide/cisplatin in patients with ED-SCLC: A meta-analysis of efficacy and toxicity. J. Med. Coll. PLA. 2012;27(4):210-225. doi: https://doi.org/10.1016/S1000-1948(12)60021-5.

    Article  Google Scholar 

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia

    E. A. Safonova, K. A. Lopatina, T. G. Razina, E. P. Zueva & L. A. Sadrikina

  2. Siberian State Medical University, Ministry of Healthcare of the Russian Federation, Tomsk, Russia

    A. M. Gur’ev & M. V. Belousov

Authors
  1. E. A. Safonova
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  2. K. A. Lopatina
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  3. T. G. Razina
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  4. E. P. Zueva
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  5. L. A. Sadrikina
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  6. A. M. Gur’ev
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  7. M. V. Belousov
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Corresponding author

Correspondence to E. A. Safonova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 5, pp. 552-556, May, 2019

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Safonova, E.A., Lopatina, K.A., Razina, T.G. et al. Correction of Damaging Effects of Cisplatin-Containing Polychemotherapy on the Intestinal Epithelium with Tussilago farfara L. Polysaccharides. Bull Exp Biol Med 167, 616–620 (2019). https://doi.org/10.1007/s10517-019-04582-1

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  • DOI: https://doi.org/10.1007/s10517-019-04582-1

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