Skip to main content
SpringerLink
Log in

Oxygen transfer and scale-up in bioreactors using hydro-ejectors for gas-liquid contacting

  • Originals
  • Published:
Bioprocess Engineering Aims and scope Submit manuscript

Abstract

The commonly used scale-up criteria are investigated for their applicability in the case of hydro-ejector reactors. In combination with the liquid jet momentum, which characterizes the hydro-ejector, a scale-up correlation with the oxygen transfer rate as scale-up criterion is proposed, independent of the type of hydro-ejector and the reactor configuration. The results with regard to the power input are compared with those of stirred tank and bubble column. Its competitiveness is at high power per volume input and above all in large scale reactors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

A m2 :

cross section of the nozzle

a 1,2,3 :

parameter

a 1/m:

relative interfacial area

C mg/l:

oxygen concentration

C ⋆ mg/l:

saturation concentration

C′ :

non-dimensional concentration (C′ =C 02/C ⋆)

D m:

tank diameter

Diff m2/s:

diffusivity of the gas in the liquid

g m/s2 :

gravity

G j :

model response curve

H m:

height

H j :

transient characteristic ofj probe

J kgm/s2 :

momentum at nozzle (eq. 8)

J s :

specific momentum (eq. 9)

k L m/s:

transfer coefficient

OTR kg O2/h:

oxygen transfer rate

P W:

power input

p :

bar pressure

Q m3/h:

flow

t s:

time

T M s:

mixing time

T r s:

reference time\((T_r = {D \mathord{\left/ {\vphantom {D {\sqrt {gH} }}} \right. \kern-\nulldelimiterspace} {\sqrt {gH} }})\)

T s s:

residence time

u gs m/s:

superficial gas velocity

V m3 :

volume

β :

gas to liquid flow ratio

σ :

standard deviation

σ L kg/s2 :

surface tension

ν m2/s:

kinematic viscosity

ϱ kg/m3 :

liquid density

τ s:

time constant

G:

gas

L:

liquid

O2 :

oxygen

HE:

hydro-ejector

P1,2,3,4:

probes used in labour scale

PI1,2:

probes used in industrial scale

References

  1. Chisti, M.Y.;Moo-Young, M.: Hydrodynamics and Oxygen Transfer in Pneumatic Bioreactor Devices. Biotechnol. Bioeng. 31 (1988) 487–494

    Google Scholar 

  2. Dang, N.D.P.;Karrer, D.A.;Dunn, I.J.: Oxygen Transfer Coefficients by Dynamic Model Moment Analysis. Biotechnol. Bioeng. 19 (1977) 853–865

    Google Scholar 

  3. Hatzifotiadou, O.: Contribution à l'étude de l'hydrodynamique et du transfert de matière gaz-liquid dans un réacteur à lit fluidisé triphasique. Ph.D. thesis, INSA Toulouse 1989

    Google Scholar 

  4. Heinzle, E.;Dunn, I.J.: Methods and Instruments in Fermentation Gas Analysis. In: Rehm, H.J. (Ed.): Biotechnology 2nd edition, vol. 4, pp. 27–71. VCH Weinheim-New York-Basel-Cambridge 1991

    Google Scholar 

  5. Hjertager, B.H.;Morud, K.: Computational Fluid Dynamics Simulation of Bioreactors. In: Mortensen, U.; Noorman, H.J. (Ed.): Proceedings of International Symposium “Bioreactor Performance” pp. 47–61. Biotechnology Research Foundation, Lund, Sweden 1993

    Google Scholar 

  6. Imai, Y.;Takei, H.;Matsumura, M.: A Simple Na2SO3 Feeding Method forK La Measurement in Large-Scale Fermentors. Biotechn. Bioeng. 29 (1987) 982–993

    Google Scholar 

  7. Kögl, B.;Moser, F.: In: Grundlagen der Verfahrenstechnik, pp. 286–287. Wien-New York: Springer 1981

    Google Scholar 

  8. Linek, V.;Benes, P.;Vacek, V.: Dynamic Pressure Method fork La Measurement in Large-Scale Bioreactors. Biotechn. Bioeng. 33 (1989) 1406–1412

    Google Scholar 

  9. Linek, V.;Sinkule, J.;Benes, P.: Critical Assessment of Gassing-In Methods for Measuringk La in Fermentors. Biotechn. Bioeng. 38 (1991) 323–330

    Google Scholar 

  10. Mayr, B.;Nagy, E.;Horvat, P.;Moser, A.: Scale-Up on Basis of Structured Mixing Models: A New Concept. Biotechn. Bioeng. 43 (1994) 195–206

    Google Scholar 

  11. Moser, A.: In: Bioprocess Technology. Wien-New York: Springer 1988

    Google Scholar 

  12. Oosterhuis, N.M.G.: Scale-up of Bioreactors, a Scale-down Approach. Ph.D. Thesis, Delft University of Technology, The Netherlands 1984

    Google Scholar 

  13. Prasertham, P.: Contribution à l'étude de l'hydrodynamique et du transfert de matière dans une colonne à bulles en ascension libre. Ph.D. thesis, INSA Toulouse 1979

    Google Scholar 

  14. Rainer, B.W.: Etude des performances d'aération des bioréacteurs au moyen d'un nouveau type d'hydroéjecteur. Ph.D. thesis, INSA Toulouse 1992

    Google Scholar 

  15. Rainer,B.W.;Fonade,C.;Moser,A.: Bioprocess Engng. (1995)

  16. Reuss, M.;Jenne, M.: Compartment Models. In: Mortensen, U.; Noorman, H.J. (Ed.): Proceedings of International Symposium “Bioreactor Performance” pp. 63–76. Biotechnology Research Foundation, Lund, Sweden 1993

    Google Scholar 

  17. van't. Riet, K.; Review of Measuring Methods and Results in Nonviscous Gas-Liquid Mass Transfer in Stirred Vessels. Ind. Eng. Chem. Process Des. Dev. 18 (1979) 357–364

    Google Scholar 

  18. van't. Riet, K.;Tramper, J.: Basic Bioreactor Design. New York, Basel, Hongkong: Marcel Dekker, Inc. 1991

    Google Scholar 

  19. Simon, M.;Fonade, C.: Experimental Study of Mixing Performances Using Steady and Unsteady Jets. Can. J. Chem. Eng. 71 (1993) 507–513

    Google Scholar 

  20. Zlokarnik, M.: Sorption Characteristics for Gas-Liquid Contactng in Mixing Vessels. Adv. Biochem. Eng. 8 (1978) 133–151

    Google Scholar 

  21. Zlokarnik, M.: Sorption Characteristics of Slot Injectors and their Dependency on the Coalescence Behaviour of the System. Chem. Eng. Sci. 34 (1979) 1265–1271

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Biotechnology, University of Technology Graz, Petersgasse 12, 8010, Graz, Austria

    A. Orfaniotis, B. Mayr & A. Moser

  2. Département de Génie Biochimique et Alimentaire, Centre de Bioingénierie Gilbert Durand, UA CNRS 544 Equipe Associée INRA, Institut National des Sciences Appliquées Complexe Scientifique de Rangueil, 31077, lToulouse Cedex, France

    M. Lalane, N. Doubrovine & C. Fonade

Authors
  1. A. Orfaniotis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Lalane
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Doubrovine
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Fonade
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. Mayr
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Moser
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Orfaniotis, A., Lalane, M., Doubrovine, N. et al. Oxygen transfer and scale-up in bioreactors using hydro-ejectors for gas-liquid contacting. Bioprocess Engineering 14, 211–218 (1996). https://doi.org/10.1007/BF01464736

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01464736

Keywords

Search

Navigation