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Synthesis of some sulfur-containing pyrido[1,2-α]pyrimidines

  • Organic Chemistry
  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

4-Methylthiopyrido[1,2-α]pyrimidin-2-one and 2-hydroxypyrido[1,2-α]pyrimidine-4-thione derivatives were synthesized by the addition ofN-(4-R-pyrid-2-yl)acetoacetamides (R = H, Me) to CS2 under phase-transfer conditions followed by the alkylation of the reaction products with Mel. The molecular structure of 3-acetyl-4-methylthiopyrido[1,2-α]pyrimidin-2-one is established by X-ray analysis.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913, Moscow, Russian Federation

    K. L. Cherkasova, V. S. Bogdanov & V. A. Dorokhov

  2. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 117813, Moscow, Russian Federation

    O. V. Shishkin

Authors
  1. K. L. Cherkasova
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  2. V. S. Bogdanov
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  3. V. A. Dorokhov
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  4. O. V. Shishkin
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Additional information

Deceased in 1995

In the description of the molecular structure of3, atomic numbers are chosen arbitrarily and do not coincide with those accepted for the pyrido(1,2-α]pyrimidine system.

Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1508–1510, June, 1996.

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Cherkasova, K.L., Bogdanov, V.S., Dorokhov, V.A. et al. Synthesis of some sulfur-containing pyrido[1,2-α]pyrimidines. Russ Chem Bull 45, 1437–1439 (1996). https://doi.org/10.1007/BF01434228

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  • DOI: https://doi.org/10.1007/BF01434228

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