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Effect of hypophysectomy on pregnenolone-16α-carbonitrile-induced ultrastructural changes in rat liver

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Summary

Pregnenolone-16α-carbonitrile (PCN) given orally to rats induces proliferation of the smooth-surfaced endoplasmic reticulum (SER) in hepatocytes, without producing marked alterations in other cell organelles. It appears that this steroid carbonitrile has a similar effect on the liver of hypophysectomized animals. Hypophysectomy alone causes a decrease of the SER.

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Abbreviations

N:

Nucleus

RER:

rough surfaced endoplasmic reticulum

SER:

smooth surfaced endoplasmic reticulum

M:

mitochondrion

Mb:

microbody

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Authors and Affiliations

  1. Institut de médecine et de chirurgie expérimentales, Université de Montréal, Montréal, Canada

    B. D. Garg, S. Szabo, J. D. Khandekar & K. Kovacs

Authors
  1. B. D. Garg
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  2. S. Szabo
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  3. J. D. Khandekar
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  4. K. Kovacs
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Fellow of the Medical Research Council of Canada.

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Garg, B.D., Szabo, S., Khandekar, J.D. et al. Effect of hypophysectomy on pregnenolone-16α-carbonitrile-induced ultrastructural changes in rat liver. Naunyn-Schmiedebergs Arch. Pharmak. 269, 7–14 (1971). https://doi.org/10.1007/BF01422012

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  • DOI: https://doi.org/10.1007/BF01422012

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