Summary
The potentiation of coronary reactive hyperemia by oral doses of Lidoflazine after different periods of coronary artery occlusion in non-anaesthetized miniature pigs is described.
Doses varying from 2.5 to 80 mg/kg of Lidoflazine were investigated and occlusion periods from 10 to 80 sec were used.
Coronary blood flow was measured by an electromagnetic flowmeter and the occlusions were performed with a pneumatic occlusive device.
The enhancement of the reactive hyperemic response is believed to result from potentiation of a transmitter substance, probably adenosine, by Lidoflazine.
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Jageneau, A.H.M., Schaper, W.K.A. & van Gerven, W. Enhancement of coronary reactive hyperemia in unanaesthetized pigs by an adenosine-potentiator (Lidoflazine). Naunyn-Schmiedebergs Arch. Pharmak. 265, 16–23 (1969). https://doi.org/10.1007/BF01417207
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DOI: https://doi.org/10.1007/BF01417207