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Adenocarcinoma of the Ethmoid sinuses

Results of a new protocol based on inductive chemotherapy combined with surgery. Four years experience

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Summary

New therapeutic modalities for Ethmoidal Adenocarcinomas are presented. Thirty three patients harbouring such a tumour have been treated during the last four years. Twenty three were included in the following protocol: —the first step consisted in inductive chemotherapy based on a four-day course of continuous cisplatine (CDDP) and 5-fluoro-uracyl (5-FU infusion)—the second step was the tumour removal, which was performed through a combined transfacial and subfrontal approach. A contralateral ethmoidectomy was always performed. The integrity of the sphenoidal sinus was systematically checked. The cranial base was reconstructed with madreporic coral grafts; then a large extra-dural pediculated galea flap was placed onto the anterior base to line the sub-frontal dura. The authors discuss the results of this series of rare tumours.

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Roux, F.X., Brasnu, D., Menard, M. et al. Adenocarcinoma of the Ethmoid sinuses. Acta neurochir 98, 129–134 (1989). https://doi.org/10.1007/BF01407338

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