Summary
The relation between clinical signs of parenchymatous cell damage after brain surgery and the serum activity of the LD-isoenzymes determined either as HBD or as heat inactivated LD, has been studied in 44 patients operated upon for intracranial aneurysms. Seven patients had a post-operative increase of the serum enzyme activity above the upper normal limit. All these showed neurological symptoms as compared to only 14% of those who had a postoperative enzyme level within normal limits. This speaks strongly in favour of a relation between the brain cell damage and the increase of the serum activity of the LD-isoenzyme. Since only 15% of the patients had a pathological enzyme level, it is further suggested that an uncomplicated operation for intracranial aneurysm should not cause an increase of the HBD or heat inactivated LD above the upper normal limit.
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Apella, E., and C. L. Markert, Dissociation of lactate dehydrogenase in subunits with guanidine hydrochloride. Biochem. Biophys. Res. Comm.6 (1961), 171–176.
Dubach, U. C., und L. Margreth, Multiple Enzymbestimmungen beim Herzinfarkt mit besonderer Berücksichtigung der diagnostischen Bedeutung der α-hydroxybutersäuredehydrogenase. Dtsch. med. Wochschr.90 (1965), 1429–1432.
Elliot, B. A., and J. H. Wilkinson, Serum “α-hydroxybutyric dehydrogenase” in myocardial infarction and in liver disease. Lancet1 (1963), 698.
Harrah, I. D., E. C. Holma, D. F. Paulson, and A. S. Ketchan, Serum enzyme alterations after extensive surgical procedures. Ann. Surg.169 (1969), 300–304.
Hebbe, B., Prevention of postoperative intracranial bleeding by means of antifibrinolytic treatment. Acta Chir. Scand.137 (1972), 403–405.
Lindblom, U., T. Vrethammar, and B. åberg, Isoenzymer av mjölksyradehydrogenas vid hjärnskada. Nord. Med.77 (1967), 337–340.
—, and B. åberg, The patterns of S-LDH isoenzymes and S-GOT after traumatic brain injury. Scand. J. Rehab. Med.4 (1972), 61–72.
Norberg, B., and å. Senning, A study of serum enzymes during and after open heart surgery with the Crafoord-Scaning heart-lung machine. Acta Chir. Scand. suppl.245 (1959), 275–282.
Pfleiderer, G., und E. D. Wachsmuth, Alters- und funktionsabhängige Differenzierung der Lactatdehydrogenase menschlicher Organe. Biochem. Z.334 (1961), 185–198.
Plagemann, P., K. Gregory, and F. Wroblewski, The electrophoretically distinct forms of mammalian lactic dehydrogenase. J. Biol. Chem.235 (1960), 2282–2287.
Rabow, L., B. Hebbe, and G. Liedén, Enzyme analysis for evaluating acute head injury. Acta Chir. Scand.137 (1971), 305–309.
—, Isoenzyme of lactic dehydrogenase as a prognosticon in patients with contusio cerebri. Scand. J. Rehab. Med.4 (1972), 90–92.
Rosalki, S. B., and J. A. Wilkinson, Reduction of α-ketobutyrate by human serum. Nature188 (1960), 1110–1111.
Stelmasiak, Z., The activity of lactic dehydrogenase and its ureastable fraction in the serum and cerebrospinal fluid in the diseases of the nervous system, with special attention to cerebro-vascular disease. Annale. Univ. Mariae Curie-Sklodowska XXVI12 (1971), 89–102.
Vesell, E., and A. Bearn, Isoenzymes of lactic dehydrogenase in human tissues. J. Clin. Invest,40 (1961), 586–591.
Wroblewski, F., and K. F. Gregory, Lactic dehydrogenase isoenzymes and their distribution in normal tissues and plasma and in disease states. Ann. N.Y. Acad. Sci.94 (1961), 912–932.
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Rabow, L., Tibbling, G. Serum enzyme activity of hydroxybutyric dehydrogenase (HBD) and heat inactivated lactate dehydrogenase (LD) after operations on intracranial aneurysms. Acta neurochir 32, 199–207 (1975). https://doi.org/10.1007/BF01405453
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DOI: https://doi.org/10.1007/BF01405453